{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:18:14Z","timestamp":1760782694648},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3931,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Sabcomeline (SB\u2010202026, 0.03 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.), a potent and functionally selective M<jats:sub>1<\/jats:sub> receptor partial agonist, caused a statistically significant improvement in the performance of a visual object discrimination task by marmosets. No such improvement was seen after RS86 (0.1 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Initial learning, which only required an association of object with reward and an appropriate response to be made, was not significantly affected. Reversal learning, which required both the extinction of the previously learned response and the acquisition of a new response strategy, was significantly improved after administration of sabcomeline (0.03 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sabcomeline (0.03 and 0.1 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.) had no significant effect on mean blood pressure measured for 2 h after administration in the conscious marmoset.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sabcomeline (0.03 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.) caused none of the overt effects such as emesis or behaviours often seen after the administration of muscarinic agonists, e.g. face rubbing and licking.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This is the first study to demonstrate cognitive enhancement by a functionally selective M<jats:sub>1<\/jats:sub> receptor partial agonist in a normal (i.e. non\u2010cognitively impaired) non\u2010human primate and this effect was seen at a dose which did not cause side effects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perseverative behaviour and deficient acquisition of new information are seen in patients with Alzheimer's disease (AD). Therefore the data suggest that sabcomeline might be of therapeutic benefit in the treatment of AD.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0701844","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:21:10Z","timestamp":1106940070000},"page":"409-415","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The profile of sabcomeline (SB\u2010202026), a functionally selective M<sub>1<\/sub> receptor partial agonist, in the marmoset"],"prefix":"10.1111","volume":"124","author":[{"given":"M H","family":"Harries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Samson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Cilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/90.2.429"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90540-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(76)90286-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(85)90123-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39940002189"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03188919"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1985.tb09446.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199503060-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1996.tb00181.x"},{"key":"e_1_2_6_11_1","first-page":"453","article-title":"Progress and persepectives in new muscarinic agonists","volume":"7","author":"Fisher A.","year":"1994","journal-title":"Drug News Perspect."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb34418.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.112.482.27"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432705"},{"key":"e_1_2_6_15_1","first-page":"299","volume-title":"Alzheimer Disease: From Molecular Biology to Therapy","author":"Kumar R.","year":"1996"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903300103"},{"key":"e_1_2_6_17_1","first-page":"1059","article-title":"SB\u2010202026: A novel muscarinic partial agonist with functional selectivity for M1 receptors","volume":"283","author":"Loudon J.M.","year":"1997","journal-title":"J. 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