{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:32:16Z","timestamp":1790497936215,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":3902,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Microvascular permeability in the mesentery and consequent leakage of protein into the peritoneum of spontaneously hypertensive rats (SHR) and normotensive rats (NTR) was measured <jats:italic>in vivo<\/jats:italic> by the extravasation of Evans blue dye.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In sensitized NTR, challenge with antigen produced extensive increases in dye extravasation in the mesentery and in peritoneal lavage fluid within 10 min.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In sensitized SHR there was no increase in the permeability of the mesentery and a very weak increase in dye extravasation in the peritoneal cavity following challenge.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The glucocorticoid antagonist RU38486 did not change the permeability response induced by antigen in sensitized NTR and SHR.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>However, compound 48\/80 was equally effective in either NTR or SHR in causing increased vasopermeability.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Mesenteric mast cells in the NTR were degranulated after immunological challenge, whereas those in the SHR were resistant, as measured histologically.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Similarly, challenge <jats:italic>ex vivo<\/jats:italic> of mesentery from sensitized NTR induced contraction of guinea\u2010pig ileum in co\u2010incubation experiments, whereas SHR mesentery was unresponsive.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma levels of antigen\u2010specific IgE and IgG2a in sensitized NTR and SHR were identical.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Immune serum from SHR was unable to induce a passive cutaneous anaphylaxis (PCA) reaction in the skin of NTR and SHR did not develop a PCA reaction upon passive sensitization with NTR immune serum.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We conclude that the mast cells of SHR are resistant to degranulation following immunological challenge, although the relevant antibodies are present.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1038\/sj.bjp.0701875","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:30:35Z","timestamp":1106940635000},"page":"772-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impairment in connective tissue mast cells degranulation in spontaneously hypertensive rats: stimulus dependent resistance"],"prefix":"10.1111","volume":"124","author":[{"given":"F H","family":"Kwasniewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Tavares de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y S","family":"Bakhle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Jancar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.3.909"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235215"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.4.443"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.4.426"},{"key":"e_1_2_6_6_1","first-page":"52","article-title":"IgE and IgG2a isotypes in the rat","volume":"32","author":"Bazin H.","year":"1982","journal-title":"Prog. 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