{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:01:47Z","timestamp":1789790507869,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Electrical field stimulation (EFS) of guinea\u2010pig isolated main bronchi induced a non\u2010adrenergic non\u2010cholinergic (NANC) contractile response. Nociceptin (0.01\u20131\u2003\u03bc<jats:sc>M<\/jats:sc>) significantly inhibited the contractile response to EFS (<jats:styled-content><jats:italic>P<\/jats:italic>&lt;0.01<\/jats:styled-content>), but not to capsaicin (<jats:styled-content><jats:italic>P<\/jats:italic>&gt;0.05<\/jats:styled-content>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The \u03bc\u2010, \u03b4\u2010 and \u03ba\u2010opioid receptor antagonists, naloxone (0.3\u2003\u03bc<jats:sc>M<\/jats:sc>), naltrindole (3\u2003\u03bc<jats:sc>M<\/jats:sc>) and nor\u2010binaltorphimine (1\u2003\u03bc<jats:sc>M<\/jats:sc>), respectively, did not significantly affect the inhibitory effect of nociceptin (0.03\u2003\u03bc<jats:sc>M<\/jats:sc>; <jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The novel nociceptin antagonist, [Phe<jats:sup>1<\/jats:sup>\u03c8(CH<jats:sub>2<\/jats:sub>\u2010NH)Gly<jats:sup>2<\/jats:sup>]nociceptin(1\u201313)NH<jats:sub>2<\/jats:sub> (0.03\u20131\u2003\u03bc<jats:sc>M<\/jats:sc>); the \u03c3 ligands, carbetapentane (30\u2003\u03bc<jats:sc>M<\/jats:sc>), 3\u2010phenylpiperidine (30\u2013100\u2003\u03bc<jats:sc>M<\/jats:sc>) and (+)\u2010cyclazocine (10\u2013100\u2003\u03bc<jats:sc>M<\/jats:sc>) significantly reversed the inhibitory effect of nociceptin (0.03\u2003\u03bc<jats:sc>M<\/jats:sc>, <jats:styled-content><jats:italic>P<\/jats:italic>&lt;0.05<\/jats:styled-content>). In contrast, rimcazole, did not significantly reverse the inhibitory effect of nociceptin (0.03\u2003\u03bc<jats:sc>M<\/jats:sc>) at any concentration tested (<jats:styled-content><jats:italic>P<\/jats:italic>&gt;0.05<\/jats:styled-content>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>EFS of guinea\u2010pig bronchial preparations significantly increased SP\u2010LI release above basal SP\u2010LI (<jats:styled-content><jats:italic>P<\/jats:italic>&lt;0.05<\/jats:styled-content>). In the presence of nociceptin (1\u2003\u03bc<jats:sc>M<\/jats:sc>), EFS induced a significant increase in SP\u2010LI release above basal SP\u2010LI release (<jats:styled-content><jats:italic>P<\/jats:italic>&lt;0.05<\/jats:styled-content>). Nociceptin caused a 59\u00b111% (<jats:italic>n<\/jats:italic>=5) inhibition of EFS\u2010induced release of SP\u2010LI.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nociceptin reduces the release of sensory neuropeptides induced by EFS, but not capsaicin, from guinea\u2010pig airways. These experiments provide further evidence for a role for nociceptin in regulating the release of sensory neuropeptides in response to EFS.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 510\u2013516; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702068\">10.1038\/sj.bjp.0702068<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702068","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:25:27Z","timestamp":1106940327000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Nociceptin inhibits non\u2010adrenergic non\u2010cholinergic contraction in guinea\u2010pig airway"],"prefix":"10.1111","volume":"125","author":[{"given":"S","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C P","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Spina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172684"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01574-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15387.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15969.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90578-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90399-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb12611.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15576.x"},{"key":"e_1_2_6_10_1","first-page":"150","article-title":"Pharmacological characterization of the autonomous innervation of the guinea\u2010pig tracheobronchial smooth muscle","volume":"49","author":"Grundstrom N.","year":"1981","journal-title":"Pharmacol. 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