{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:58:47Z","timestamp":1780570727523,"version":"3.54.1"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The influence of endothelin receptor antagonists on febrile responses to <jats:italic>E. coli<\/jats:italic> lipopolysaccharide (LPS), interleukin\u20101\u03b2 (IL\u20101\u03b2), tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and endothelin\u20101 (ET\u20101) was assessed in conscious rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intravenous (i.v.) LPS (5.0\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) markedly increased rectal temperature to a peak of 1.30\u00b0C over baseline at 2.5\u2003h. Pretreatment with the mixed endothelin ET<jats:sub>A<\/jats:sub>\/ET<jats:sub>B<\/jats:sub> receptor antagonist bosentan (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) or the selective endothelin ET<jats:sub>B<\/jats:sub> receptor antagonist BQ\u2010788 (N\u2010<jats:italic>cis<\/jats:italic>\u20102,6\u2010dimethyl\u2010piperidinocarbonyl\u2010<jats:sc>L<\/jats:sc>\u2010\u03b3\u2010methylleucyl\u2010D\u20101\u2010methoxycarboyl\u2010<jats:sc>D<\/jats:sc>\u2010norleucine; 3\u2003pmol, into a lateral cerebral ventricle\u2013i.c.v.) reduced the peak response to LPS to 0.90 and 0.75\u00b0C, respectively. The selective endothelin ET<jats:sub>A<\/jats:sub> receptor antagonist BQ\u2010123 (cyclo[<jats:sc>D<\/jats:sc>\u2010Trp\u2010<jats:sc>D<\/jats:sc>\u2010Asp\u2010Pro\u2010<jats:sc>D<\/jats:sc>\u2010Val\u2010Leu]; 3\u2003pmol, i.c.v.) was ineffective.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increases in temperature caused by IL\u20101\u03b2 (180\u2003fmol, i.c.v.), TNF\u2010\u03b1 (14.4\u2003pmol, i.c.v.) or IL\u20101\u03b2 (150\u2003pmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) were unaffected by BQ\u2010788 (3\u2003pmol, i.c.v.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Central injection of endothelin\u20101 (0.1 to 3\u2003fmol, i.c.v.) caused slowly\u2010developing and long\u2010lasting increases in rectal temperature (starting 2\u2003h after administration and peaking at 4\u20136\u2003h between 0.90 and 1.15\u00b0C) which were not clearly dose\u2010dependent. The response to endothelin\u20101 (1\u2003fmol, i.c.v.) was prevented by BQ\u2010788, but not by BQ\u2010123 (each at 3\u2003pmol, i.c.v.). Intraperitoneal pretreatment with the cyclo\u2010oxygenase inhibitor indomethacin (2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), which partially reduced LPS\u2010induced fever, did not modify the hyperthermic response to endothelin\u20101 (3\u2003fmol, i.c.v.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therefore, central endothelin(s) participates importantly in the development of LPS\u2010induced fever, <jats:italic>via<\/jats:italic> activation of a prostanoid\u2010independent endothelin ET<jats:sub>B<\/jats:sub> receptor\u2010mediated mechanism possibly not situated downstream from IL\u20101\u03b2 or TNF\u2010\u03b1 in the fever cascade.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 542\u2013548; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702075\">10.1038\/sj.bjp.0702075<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702075","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:25:27Z","timestamp":1106940327000},"page":"542-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Essential role for endothelin ET<sub>B<\/sub> receptors in fever induced by LPS (<i>E. coli<\/i>) in rats"],"prefix":"10.1111","volume":"125","author":[{"given":"Aline S C","family":"Fabricio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A A","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles A","family":"Rae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"D'Orl\u00e9ans\u2010Juste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f3ria E P","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"600","article-title":"Endothelins: circulating plasma levels and presence in other biologic fluids","volume":"68","author":"Battistini B.","year":"1993","journal-title":"Lab. 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