{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:44:57Z","timestamp":1767156297611},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Injection of interleukin\u20101 (IL\u20101) into pylorus\u2010ligated rats has been shown strongly to inhibit gastric secretion. However, in the present study, we found that an intraperitoneal injection of IL\u20101 into intact (non\u2010pylorus\u2010ligated) fasted mice rapidly (within 30\u2003min) induced an accumulation of gastric acid (\u2018early response\u2019). When the dose of IL\u20101 was larger, the accumulation lasted for a longer period.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Injection of IL\u20101 also caused a later elevation of the activity of histidine decarboxylase (HDC), the histamine\u2010forming enzyme, in the stomach (\u2018later response\u2019).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cimetidine, an antagonist of histamine H<jats:sub>2<\/jats:sub>\u2010receptors, suppressed the accumulation of gastric acid in both the early and later periods. An irreversible inhibitor of HDC, \u03b1\u2010fluoromethylhistidine, partially inhibited the accumulation in the later period.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>IL\u20101, when injected 1 h after feeding in mice fasted overnight, markedly retarded gastric emptying.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Tumour necrosis factor (TNF) and lipopolysaccharide (LPS) or endotoxin from <jats:italic>E. coli<\/jats:italic> both had IL\u20101\u2010like effects on the stomach, and their effects are presumably mediated by IL\u20101.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results support the idea that an inhibition of gastric emptying and an elevation of HDC activity in the stomach may explain the findings that a long\u2010lasting accumulation of gastric acid is induced by IL\u20101 despite its potent inhibition of gastric acid secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>On the basis of these results, and in the light of the known actions of histamine, the possible roles of IL\u20101 in gastric inflammation and ulceration are discussed.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 842\u2013848; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702108\">10.1038\/sj.bjp.0702108<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702108","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:50:22Z","timestamp":1106941822000},"page":"842-848","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Induction by interleukin\u20101, tumor necrosis factor and lipopolysaccharides of histidine decarboxylase in the stomach and prolonged accumulation of gastric acid"],"prefix":"10.1111","volume":"125","author":[{"given":"Yasuo","family":"Endo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Monographs in Allergy","author":"Beaven M.A.","year":"1978"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/236385a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90326-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967342"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(83)90224-8"},{"key":"e_1_2_6_7_1","first-page":"600","volume-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics.","author":"Campbell W.B.","year":"1990"},{"key":"e_1_2_6_8_1","first-page":"1311","article-title":"Histamine and gastric secretion: a later look, 1955\u20101965","volume":"24","author":"Code C.F.","year":"1965","journal-title":"Fed. 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