{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:49:44Z","timestamp":1774662584471,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T00:00:00Z","timestamp":1233619200000},"content-version":"vor","delay-in-days":3778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Lipopolysaccharide (LPS) is implicated in many pulmonary and airway inflammatory diseases. Tachykinins released from nerve endings increase vascular permeability. In this study, we have assessed the enhancement by LPS of tachykinin\u2010mediated plasma exudation in guinea\u2010pig airways, and examined the role of oxidants as well as leukocyte adherence.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LPS (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) was administered 0\u20133\u2003h before bilateral electrical stimulation of the cervical vagus nerves in animals anaesthetized with urethane and ventilated. Vagal stimulation increased vascular permeability in the airways. LPS enhanced the vagally\u2010mediated plasma exudation with the peak effect at 1\u2003h after LPS administration. LPS alone induced no significant plasma exudation. LPS also enhanced exogenous substance P (10<jats:sup>\u22128<\/jats:sup>\u2003mol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.)\u2010induced plasma exudation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The NK\u20101 receptor antagonist L\u2010732,138 abolished vagally\u2010induced plasma exudation and significantly inhibited the enhancement by LPS. Pretreatment with superoxide dismutase (SOD, 5000\u2003U\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) did not affect the vagally\u2010induced plasma exudation, but inhibited the LPS\u2010enhanced neurogenic plasma leakage. The LPS\u2010enhanced vagally\u2010induced plasma exudation was not completely inhibited by either L\u2010732,138 or SOD pretreatment alone, but was blocked by the combination of both pretreatments.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Neutrophil depletion by cyclophosphamide alone did not influence vagally\u2010induced plasma exudation, but significantly inhibited the LPS\u2010enhanced response.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, we have demonstrated LPS enhanced neurogenic plasma exudation by augmenting the response to tachykinins, partly through NK\u20101 receptors, to directly increase vascular permeability or to enhance leukocyte adhesion\u2010mediated endothelial cell injury. Tachykinins released from nerve endings may contribute to endotoxin\u2010related airway inflammatory responses.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 711\u2013716; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702138\">10.1038\/sj.bjp.0702138<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702138","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:50:22Z","timestamp":1106941822000},"page":"711-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipopolysaccharide enhances neurogenic plasma exudation in guinea\u2010pig airways"],"prefix":"10.1111","volume":"125","author":[{"given":"H \u2010P","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K \u2010H","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H \u2010C","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C \u2010H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C \u2010Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L \u2010C","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"L263","article-title":"NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in rat trachea","volume":"268","author":"Baluk P.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.6.2653"},{"key":"e_1_2_6_4_1","first-page":"105","article-title":"Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS","volume":"4","author":"Bost K.L.","year":"1992","journal-title":"Reg. Immunol."},{"key":"e_1_2_6_5_1","first-page":"A1276","article-title":"Relative density of substance P\u2010immunoreactive nerve fibres in the tracheal epithelium of a range of species","volume":"6","author":"Bowden J.","year":"1992","journal-title":"FASEB J."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90184-8"},{"key":"e_1_2_6_7_1","first-page":"913","article-title":"Endotoxin and lung injury","volume":"133","author":"Brigham K.L.","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1016\/S0021-9258(17)37412-4","article-title":"Characterization of the interaction of N\u2010acyl\u2010L\u2010tryptophan benzyl ester neurokinin antagonists with the human neurokinin\u20101 receptor","volume":"269","author":"Cascieri M.A.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114251"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1991.tb00833.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/jappl.1982.53.4.967","article-title":"Respiratory failure after endotoxin infection in sheep: lung mechanics and lung fluid balance","volume":"53","author":"Esbenshade A.M.","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918976"},{"key":"e_1_2_6_13_1","first-page":"327","article-title":"Bronchial challenge of normal subjects with the endotoxin of Enterobacter agglomerans isolated from cotton dusts","volume":"43","author":"Jamison J.P.","year":"1986","journal-title":"Br. J. Ind. Med."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb00471.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111569"},{"key":"e_1_2_6_16_1","first-page":"269","article-title":"Lipopolysaccharide mediated bovine endothelial cell injury in vitro","volume":"48","author":"Harlar L.M.","year":"1983","journal-title":"Lab. Invest."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.5.568"},{"key":"e_1_2_6_18_1","first-page":"89","article-title":"Granulocyte recruitment to airways exposed to endotoxin aerosols","volume":"115","author":"Hudson A.R.","year":"1997","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1152\/jappl.1983.54.6.1463","article-title":"Effect of endotoxin on airway responsiveness to aerosol histamine in sheep","volume":"54","author":"Hutchinson A.A.","year":"1983","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_20_1","first-page":"L316","article-title":"Peptidase inhibitors reverse steroid\u2010induced suppression of neutrophil adhesion in rat tracheal blood vessels","volume":"264","author":"Katayama M.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.3.511"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701338"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90728-M"},{"key":"e_1_2_6_24_1","first-page":"133","article-title":"Noncholinergic airway constriction: role of axon reflex and oxygen radicals","volume":"36","author":"Lai Y.L.","year":"1993","journal-title":"Chin. J. Physiol."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(93)90070-Q"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1679"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15211.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007572"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.2.819"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(95)00037-K"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.540"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1183\/09031936.93.04101268","article-title":"Plasma exudation in the airways: mechanisms and function","volume":"4","author":"Persson C.G.","year":"1991","journal-title":"Eur. Respir. J."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.5.2462"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90180-5"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.252.4.C436"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112426"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(95)00040-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1152\/jappl.1990.69.6.2131","article-title":"Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules","volume":"69","author":"Umeno E.","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.19"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0702138","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0702138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0702138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:24:05Z","timestamp":1697405045000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0702138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1038\/sj.bjp.0702138"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0702138","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"2009-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}