{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:03:30Z","timestamp":1773421410186,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":3755,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of a new type 2 selective somatostatin (SRIF) receptor antagonist (DC\u201041\u201033) on somatostatin\u2010induced inhibition of pentagastrin\u2010stimulated gastric acid secretion in conscious, chronic gastric fistula equipped rats was studied.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Infused intravenously, DC\u201041\u201033 dose\u2010dependently inhibits SRIF\u2010induced inhibition of pentagastrin\u2010stimulated gastric acid secretion with an IC<jats:sub>50<\/jats:sub> of 31.6\u00b11.2\u2003nmol\u2003kg<jats:sup>\u22121<\/jats:sup> versus 10\u2003nmol\u2003kg<jats:sup>\u22121<\/jats:sup> SRIF and blocks the inhibitory effects of SRIF when simultaneously co\u2010infused. Its effectiveness provides additional evidence that SRIF\u2010inhibition of gastric acid release is a SRIF type 2 receptor\u2010mediated process.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DC\u201041\u201033 is able to completely reverse the inhibitory effect of glucose\u2010dependent insulinotropic polypeptides, GIP and GIP\u2010(1\u201330)NH<jats:sub>2<\/jats:sub>, and glucagon\u2010like polypeptide, GLP\u20101(7\u201036)NH<jats:sub>2<\/jats:sub>, on pentagastrin\u2010stimulated gastric acid secretion thus confirming that they exert these effects through stimulation of endogenous SRIF release.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DC\u201041\u201033 only partially blocks potent amylin and adrenomedullin\u2010induced inhibition of gastric acid secretion, therefore suggesting that somatostatin may not function as a primary mediator in the action of these peptides.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results indicate that DC\u201041\u201033, is a potent <jats:italic>in vivo<\/jats:italic> inhibitor of exogenous and endogenous SRIF in rats. It represents a new class of SRIF analogues which should eventually provide excellent tools for further evaluating the many physiological roles of SRIF and its five receptor subtypes.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 1081\u20131087; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702160\">10.1038\/sj.bjp.0702160<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702160","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:27:39Z","timestamp":1106940459000},"page":"1081-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Examination of somatostatin involvement in the inhibitory action of GIP, GLP\u20101, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist analogue"],"prefix":"10.1111","volume":"125","author":[{"given":"Wojciech J.","family":"Rossowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beng\u2010L","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning\u2010Y","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Coy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"245","article-title":"Somatostatin inhibition of acid and histamine release by activation of somatostatin receptor subtype 2 receptors in rats","volume":"281","author":"Aurang K.","year":"1997","journal-title":"J. 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