{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:53:49Z","timestamp":1773302029855,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":3754,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Experiments were carried out to determine the effects of the application of the selective 5\u2010HT<jats:sub>2<\/jats:sub> receptor agonist DOI intravenously (in the presence of the peripherally acting 5\u2010HT<jats:sub>2<\/jats:sub> receptor antagonist, BW501C67, 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) or to the \u2018glycine sensitive area\u2019 of the ventral surface (30\u2003\u03bcg each side) on the left ventricular inotropic (left ventricular d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic> max) and vascularly isolated hindlimb responses in anaesthetized cats. For the ventral surface experiments, NMDA (10\u2003\u03bcg each side) was applied to act as a positive control. In all experiments heart rate and mean arterial blood pressure were held constant to exclude any secondary effects caused by changes in these variables.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DOI (<jats:styled-content><jats:italic>n<\/jats:italic> = 6<\/jats:styled-content>) i.v or on the ventral surface had no effect on left ventricular d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic> max but caused a significant increase in hindlimb perfusion pressure of 40\u00b19 and 50\u00b114\u2003mmHg, respectively. Respiration was unaffected. NMDA (<jats:styled-content><jats:italic>n<\/jats:italic> = 6<\/jats:styled-content>), applied to the ventral surface, caused significant increases in both left ventricular d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic> max and hindlimb perfusion pressure of 1950\u00b1349\u2003mmHg\u2003s<jats:sup>\u22121<\/jats:sup> and 69\u00b117\u2003mmHg respectively, with no associated change in left ventricular end\u2010diastolic pressure. The amplitude of respiratory movements increased.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is concluded that activation of 5\u2010HT<jats:sub>2<\/jats:sub> receptors at the level of the rostral ventrolateral medulla (RVLM) excites sympathetic premotor neurons and\/or their antecedents controlling hindlimb vascular resistance but not those controlling the inotropic effects on the left ventricle.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 1172\u20131179; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702183\">10.1038\/sj.bjp.0702183<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702183","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:52:52Z","timestamp":1106941972000},"page":"1172-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The central action of the 5\u2010HT<sub>2<\/sub> receptor agonist 1\u2010(2,5\u2010dimethoxy\u20104\u2010iodophenyl)\u20102\u2010aminopropane (DOI) on cardiac inotropy and vascular resistance in the anaesthetized cat"],"prefix":"10.1111","volume":"125","author":[{"given":"Andrew G","family":"Ramage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"de Burgh Daly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"R615","article-title":"Cardiac sympathetic premotor neurones","volume":"272","author":"Campos R.R.","year":"1997","journal-title":"Am. 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