{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:16Z","timestamp":1791910756626,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":3754,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Using an <jats:italic>in vitro<\/jats:italic> mouse cerebellar slice preparation and whole\u2010cell electrophysiological recording techniques we have characterized Purkinje and basket cell inhibitory post\u2010synaptic currents (IPSCs), and examined the effects of a number of selective peptidergic K<jats:sup>+<\/jats:sup> channel blockers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Spontaneous IPSC amplitude ranged from \u223c10\u2003pA up to \u223c3\u2003nA for both cell types [mean values: Purkinje cells \u2212122.8\u00b120.0\u2003pA (<jats:italic>n<\/jats:italic>=24 cells); basket cells \u2212154.8\u00b115.9\u2003pA (<jats:italic>n<\/jats:italic>=26 cells)]. Frequency varied from \u223c3 up to \u223c40\u2003Hz, [mean values: basket cells 14.9\u00b11.7\u2003Hz (<jats:italic>n<\/jats:italic>=26 cells); Purkinje cells 17.9\u00b12.2\u2003Hz (<jats:italic>n<\/jats:italic>=24 cells)]. 5\u2003\u03bc<jats:sc>m<\/jats:sc> bicuculline eliminated virtually all spontaneous currents.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>IPSC rise times were fast (\u223c0.6\u2003ms) and the decay phase was best fit with the sum of two exponential functions (\u03c4<jats:sub>1<\/jats:sub> and \u03c4<jats:sub>2<\/jats:sub>: \u223c4\u2003ms and \u223c20\u2003ms, <jats:styled-content><jats:italic>n<\/jats:italic> = 40<\/jats:styled-content>; for both cell types).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The snake toxins alpha\u2010dendrotoxin (\u03b1\u2010DTX) and toxin K greatly enhanced IPSC frequency and amplitude in both cell types; the closely related homologues toxin I and gamma\u2010dendrotoxin (\u03b3\u2010DTX) produced only marginal enhancements (all at 200\u2003n<jats:sc>m<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Two scorpion toxins, margatoxin (MgTX) and agitoxin\u20102 (AgTX\u20102) had only minor effects on IPSC frequency or amplitude (both at 10\u2003n<jats:sc>m<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Low concentrations of tetraethylammonium (TEA; 200\u2003\u03bc<jats:sc>m<\/jats:sc>) had no overall effect on cerebellar IPSCs, whilst higher concentrations (10\u2003m<jats:sc>m<\/jats:sc>) increased both the frequency and amplitude.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that native K<jats:sup>+<\/jats:sup> channels, containing Kv1.1 and Kv1.2 channel subunits, play an influential role in controlling GABAergic inhibitory transmission from cerebellar basket cells.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 1375\u20131381; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702218\">10.1038\/sj.bjp.0702218<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702218","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:52:52Z","timestamp":1106941972000},"page":"1375-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Modulation of inhibitory post\u2010synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K<sup>+<\/sup> channel blockers"],"prefix":"10.1111","volume":"125","author":[{"given":"Andrew P","family":"Southan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/199655a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018333"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1979.tb08667.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-08011.1995"},{"key":"e_1_2_6_6_1","first-page":"1","volume-title":"Handbook of Receptors and Channels","author":"Chandy K.G.","year":"1995"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90052-H"},{"key":"e_1_2_6_8_1","first-page":"103","volume-title":"Neurotoxins and Neurobiology","author":"Dolly J.O.","year":"1994"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-13147-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00188a012"},{"key":"e_1_2_6_11_1","first-page":"1227","article-title":"Pharmacological characterization of five cloned voltage\u2010gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines","volume":"45","author":"Grissmer S.","year":"1994","journal-title":"Mol. 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