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We have attempted to address these questions by investigating the effects of (a) known agonists for presynaptic receptors on GABAergic terminals, and (b) a range of GABA<jats:sub>A<\/jats:sub> receptor ligands, on each response.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The GABA uptake inhibitor NNC 05\u2010711 (10 \u03bc<jats:sc>m<\/jats:sc>) enhanced whereas bicuculline (10 \u03bc<jats:sc>m<\/jats:sc>) inhibited both IPSP<jats:sub>A<\/jats:sub>s and DPSP<jats:sub>A<\/jats:sub>s.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>(\u2212)\u2010Baclofen (5 \u03bc<jats:sc>m<\/jats:sc>), [<jats:sc>D<\/jats:sc>\u2010Ala<jats:sup>2<\/jats:sup>,N\u2010Me\u2010Phe<jats:sup>4<\/jats:sup>,Gly<jats:sup>5<\/jats:sup>\u2010ol]\u2010enkephalin (DAGO; 0.5 \u03bc<jats:sc>m<\/jats:sc>), and carbachol (10 \u03bc<jats:sc>m<\/jats:sc>) caused substantial depressions (up to 99%) of DPSP<jats:sub>A<\/jats:sub>s that were reversed by CGP 55845A (1 \u03bc<jats:sc>m<\/jats:sc>), naloxone (10 \u03bc<jats:sc>m<\/jats:sc>) and atropine (5 \u03bc<jats:sc>m<\/jats:sc>), respectively. In contrast, 2\u2010chloroadenosine (CADO; 10 \u03bc<jats:sc>m<\/jats:sc>) only slightly depressed DPSP<jats:sub>A<\/jats:sub>s. Quantitatively, the effect of each agonist was similar to that reported for IPSP<jats:sub>A<\/jats:sub>s.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The neurosteroid ORG 21465 (1\u201310 \u03bc<jats:sc>m<\/jats:sc>), the anaesthetic propofol (50\u2013500 \u03bc<jats:sc>m<\/jats:sc>), the barbiturate pentobarbitone (100\u2013300 \u03bc<jats:sc>m<\/jats:sc>) and zinc (50 \u03bc<jats:sc>m<\/jats:sc>) all enhanced DPSP<jats:sub>A<\/jats:sub>s and IPSP<jats:sub>A<\/jats:sub>s.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The benzodiazepine (BZ) agonist flunitrazepam (10\u201350 \u03bc<jats:sc>m<\/jats:sc>) and inverse agonist DMCM (1 \u03bc<jats:sc>m<\/jats:sc>) caused a respective enhancement and inhibition of both IPSP<jats:sub>A<\/jats:sub>s and DPSP<jats:sub>A<\/jats:sub>s. The BZ\u03c9<jats:sub>1<\/jats:sub> site agonist zolpidem (10\u201330 \u03bc<jats:sc>m<\/jats:sc>) produced similar effects to flunitrazepam.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The anticonvulsant loreclezole (1\u2013100 \u03bc<jats:sc>m<\/jats:sc>) did not affect either response.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data demonstrate that similar populations of inhibitory interneurones can generate both IPSP<jats:sub>A<\/jats:sub>s and DPSP<jats:sub>A<\/jats:sub>s by activating GABA<jats:sub>A<\/jats:sub> receptors that are subject to similar allosteric modulation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1998) <jats:bold>125<\/jats:bold>, 1529\u20131542; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702237\">10.1038\/sj.bjp.0702237<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702237","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:52:59Z","timestamp":1106941979000},"page":"1529-1542","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pharmacological modulation of GABA<sub>A<\/sub> receptor\u2010mediated postsynaptic potentials in the CA1 region of the rat hippocampus"],"prefix":"10.1111","volume":"125","author":[{"given":"Nicholas A","family":"Manuel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceri H","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014255"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014256"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90671-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-12-03912.1996"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8990-2_15"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.626"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80401-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/368823a0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90171-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019945"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018080"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/385820a0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90337-F"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021070"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1152\/jn.1993.69.5.1541","article-title":"Role of Hco3\n                  \u2212 ions in depolarizing GabaA receptor\u2010mediated responses in pyramidal cells of rat hippocampus","volume":"69","author":"Grover L.M.","year":"1993","journal-title":"J. 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