{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:18:51Z","timestamp":1773958731110,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":3731,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>The corpus cavernosum is the erectile tissue in the penis and clitoris. Although nitrergic neurotransmission has been characterized in detail in the penile corpus cavernosum, functional studies on the inhibitory non\u2010adrenergic non\u2010cholinergic (NANC) transmission in the clitoral corpus cavernosum have been lacking. Here we demonstrate that electrical field stimulation (EFS) induces NANC relaxation responses in the clitoral corpus cavernosum of the rabbit. These responses were inhibited by N<jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine methylester (<jats:sc>L<\/jats:sc>\u2010NAME), 1H\u2010[1,2,4]oxadiazolo[4,3,\u2010a]quinoxalin\u20101\u2010one (ODQ) or tetrodotoxin. The inhibitory effect of <jats:sc>L<\/jats:sc>\u2010NAME was partially reversed by <jats:sc>L<\/jats:sc>\u2010arginine but not by <jats:sc>D<\/jats:sc>\u2010arginine. EFS\u2010induced relaxations were enhanced by an inhibitor of type V cyclic GMP phosphodiesterase, zaprinast. These results suggest that nitrergic neurotransmission is responsible for the NANC relaxation responses in the clitoral corpus cavernosum of the rabbit.<\/jats:p>","DOI":"10.1038\/sj.bjp.0702278","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:31:58Z","timestamp":1106940718000},"page":"1627-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Nitrergic neurotransmission mediates the non\u2010adrenergic non\u2010cholinergic responses in the clitoral corpus cavernosum of the rabbit"],"prefix":"10.1111","volume":"125","author":[{"given":"Selim","family":"Cellek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.1.191"},{"key":"e_1_2_7_3_1","first-page":"47","article-title":"Sildenafil: an orally active type 5 cGMP\u2010specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction","volume":"8","author":"Boolell M.","year":"1996","journal-title":"Int. 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