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Comparisons were made with sumatriptan (0.003\u20133.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) and \u03b1\u2010CGRP<jats:sub>8\u201337<\/jats:sub> (0.001\u20130.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Trigeminal nerve ganglion stimulation produced frequency related increases in carotid blood flow, reductions in carotid vascular resistance and non\u2010frequency related increases in blood pressure. Guanethidine (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) blocked trigeminal nerve ganglion\u2010induced increases in blood pressure but had no effect on changes in carotid flow or resistance. Maximal reductions in carotid vascular resistance was observed at 10\u2003Hz, and this frequency was selected to investigate the effects of drugs on trigeminal nerve ganglion stimulation\u2010induced responses in guanethidine treated cats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Saline, \u03b1\u2010CGRP<jats:sub>8\u201337<\/jats:sub> SB\u2010209670 and BQ\u2010788 had little or no effect on resting haemodynamic parameters. SB\u2010217242 (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>n<\/jats:italic>=3) produced a 56% reduction in arterial blood pressure whereas SB\u2010233451 (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>n<\/jats:italic>=3) produced a 30% reduction in carotid vascular resistance. Sumatriptan produced dose\u2010related reductions in resting carotid flow and increases (max. 104% at 0.3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, <jats:italic>n<\/jats:italic>=5) in vascular resistance.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SB\u2010209670 (<jats:italic>n<\/jats:italic>=6\u20137), SB\u2010217242 (<jats:italic>n<\/jats:italic>=3) and BQ\u2010788 (<jats:italic>n<\/jats:italic>=3) produced inhibition of trigeminal nerve ganglion stimulation\u2010induced reductions in carotid vascular resistance. Saline, SB\u2010234551, \u03b1\u2010CGRP<jats:sub>8\u201337<\/jats:sub> and sumatriptan had no effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data demonstrate ET<jats:sub>B<\/jats:sub> receptor blockade attenuates the vasodilator effects of trigeminal nerve ganglion stimulation in the carotid vascular bed of guanethidine pretreated anaesthetized cats.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>126<\/jats:bold>, 485\u2013493; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702306\">10.1038\/sj.bjp.0702306<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702306","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:57:44Z","timestamp":1106942264000},"page":"485-493","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trigeminal nerve ganglion stimulation\u2010induced neurovascular reflexes in the anaesthetized cat: Role of endothelin<sub>B<\/sub> receptors in carotid vasodilatation"],"prefix":"10.1111","volume":"126","author":[{"given":"Pravin","family":"Raval","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Bingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nambi","family":"Aiyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Jackie","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliot H","family":"Ohlstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13061.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(91)90165-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14679.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00106-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1703145.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01247-F"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15617.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(91)90019-D"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7634"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90033-H"},{"key":"e_1_2_7_12_1","first-page":"R270","article-title":"Effect of stimulation of trigeminal ganglion on regional cerebral blood flow in cats","volume":"253","author":"GOADSBY P.J.","year":"1987","journal-title":"Am. 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