{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:32:48Z","timestamp":1762144368021},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3650,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of prolonged administration of a carboxypeptidase Y\u2010like kininase inhibitor, ebelactone B (EB) (2\u2010ethyl\u20103, 11\u2010dihydroxy\u20104, 6, 8, 10, 12\u2010pentamethyl\u20109\u2010oxo\u20106\u2010tetradecenoic 1, 3\u2010lactone), on the development of deoxycorticosterone acetate (DOCA)\u2010salt hypertension was tested.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The systolic blood pressure (SBP) of non\u2010treated 6\u2010week\u2010old Sprague\u2010Dawley strain rats was gradually increased by DOCA\u2010salt treatment from 137\u00b12\u2003mmHg (<jats:italic>n<\/jats:italic>=11) to 195\u00b17\u2003mmHg at 10 weeks of age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>With daily oral administration of lisinopril (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, twice a day), which is an inhibitor of angiotensin converting enzyme, a major kininase in plasma, the development of hypertension was not suppressed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>By contrast, administration of EB (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, twice a day), completely inhibited the development of hypertension (SBP: 146\u00b11\u2003mmHg, <jats:italic>n<\/jats:italic>=5, 10 weeks old). The reduced SBP at 10 weeks of age was equal to the SBP before any treatment (142\u00b11\u2003mmHg, <jats:italic>n<\/jats:italic>=5).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Direct determination of mean blood pressure (MBP) in conscious, unrestrained rats confirmed that MBP elevation was completely inhibited by EB.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Continuous subcutaneous infusion (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>) of HOE140, a bradykinin B<jats:sub>2<\/jats:sub> receptor antagonist, restored the elevation of SBP, which was suppressed by EB.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The weights of left ventricle of DOCA\u2010salt treated rats 10\u2010weeks\u2010old (0.36\u00b10.02\u2003g 100\u2003g body weight<jats:sup>\u22121<\/jats:sup>, <jats:italic>n<\/jats:italic>=11) was significantly reduced by EB (0.27\u00b10.01, <jats:italic>n<\/jats:italic>=5), as were the sodium levels in serum, cerebrospinal fluid and erythrocyte.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings suggested that EB is effective in preventing salt\u2010related hypertension presumably by eliminating sodium retention.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>126<\/jats:bold>, 613\u2013620; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702340\">10.1038\/sj.bjp.0702340<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702340","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T19:41:09Z","timestamp":1106941269000},"page":"613-620","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of prolonged administration of a urinary kininase inhibitor, ebelactone B on the development of deoxycorticosterone acetate\u2010salt hypertension in rats"],"prefix":"10.1111","volume":"126","author":[{"given":"Hiroshi","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Majima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Katori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1448","article-title":"Hemodynamic basis for glomerular injury in rats with deoxycorticosterone\u2010salt hypertension","volume":"73","author":"DWORKIN L.D.","year":"1984","journal-title":"J. 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