{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:15:51Z","timestamp":1761707751323},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Bradykinin is suggested to play a role in the pathophysiology of several acute and chronic diseases, including allergic disorders such as asthma. In the present study, we have investigated the importance of bradykinin in mediating allergic inflammation in rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>To this end we have tested the effects of the B<jats:sub>2<\/jats:sub> receptor antagonists Hoe 140, FR173657 or FR172357 on the pleural inflammatory response triggered by intrapleural (i.pl.) injection of allergen (ovalbumin, 12\u2003\u03bcg cavity<jats:sup>\u22121<\/jats:sup>) in 14 day\u2010actively sensitized Wistar rats. Analysis of the pleural fluid effluent revealed a sequence of mast cell\u2010dependent inflammatory events, including early protein exudation and neutrophilia and late pleural eosinophil influx.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Local treatment with Hoe 140 (0.1 and 1\u2003\u03bcg cavity<jats:sup>\u22121<\/jats:sup>), FR173657 (1 and 10\u2003\u03bcg cavity<jats:sup>\u22121<\/jats:sup>) or FR172357 (1 and 10\u2003\u03bcg cavity<jats:sup>\u22121<\/jats:sup>) inhibited dose\u2010dependently allergen\u2010induced mast cell activation with impairment of pleural plasma leakage, neutrophil accumulation and late eosinophil influx.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Moreover, the B<jats:sub>2<\/jats:sub> receptor antagonists also dose\u2010dependently inhibited the allergic like inflammatory pleurisy triggered by bradykinin (50\u2003\u03bcg cavity<jats:sup>\u22121<\/jats:sup>), which is characterized by acute mast cell degranulation, protein leakage and pleural eosinophil infiltration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Taken together, our findings provide substantial evidence to suggest that bradykinin acting on its B<jats:sub>2<\/jats:sub> receptors play a critical role in mediating allergic mast cell\u2010dependent inflammation in rats, and suggest that B<jats:sub>2<\/jats:sub> receptor antagonists may be useful therapeutically to control allergic dysfunction.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 315\u2013320; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702536\">10.1038\/sj.bjp.0702536<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702536","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:03:49Z","timestamp":1106942629000},"page":"315-320","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Suppressive effect of distinct bradykinin B<sub>2<\/sub> receptor antagonist on allergen\u2010evoked exudation and leukocyte infiltration in sensitized rats"],"prefix":"10.1111","volume":"127","author":[{"given":"Christianne","family":"Bandeira\u2010Melo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea S","family":"Calheiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M R","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato S B","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02144161"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.4_Pt_1.787"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701793"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(96)00065-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(96)00136-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14835.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.9.4902"},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Bioregulation of kinins: kallikreins, kininogens and kininases","volume":"44","author":"BHOOLA K.","year":"1992","journal-title":"Pharmacol. 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