{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:32:15Z","timestamp":1747740735850},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The role of both exogenously administered and endogenously generated bradykinin (BK) on LPS\u2010induced eosinophil accumulation in the mice pleural cavity was investigated by means of treatment with BK selective receptor agonists\/antagonists and captopril.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrathoracic (i.t.) injection of LPS (250\u2003ng cavity<jats:sup>\u22121<\/jats:sup>) induced eosinophil influx at 24\u2003h as previously described (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b7\"><jats:sup>Bozza <jats:italic>et al<\/jats:italic>., 1993<\/jats:sup><\/jats:ext-link>). Pretreatment with the B<jats:sub>1<\/jats:sub> receptor antagonist des\u2010Arg<jats:sup>9<\/jats:sup>\u2010[leu\u2010<jats:sup>8<\/jats:sup>]BK (0.025 and 0.25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>) showed no effect on this phenomenon, whereas pretreatment with the B<jats:sub>2<\/jats:sub> receptor antagonists, NPC 17731 (0.025 and 0.25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>) or HOE 140 (2.5\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>), increased LPS\u2010induced eosinophil influx. Accordingly, pretreatment with captopril at 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> i.p., inhibited eosinophil infiltration induced by LPS in the pleural cavity, suggesting that endogenous BK is down\u2010regulating LPS\u2010induced eosinophil accumulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BK administered at 15 and 25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>, i.t. or i.p. also inhibited LPS\u2010induced eosinophil accumulation. BK alone had no effect on the basal number of leucocytes in the pleural or peritoneal cavity in doses up to 25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>. Nevertheless, when injected at doses of 50 and 100\u2003nmol cavity<jats:sup>\u22121<\/jats:sup> BK induced leucocyte influx characterized by neutrophil and eosinophil accumulation at 24\u2003h.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Similarly to what was observed with BK, a specific B<jats:sub>2<\/jats:sub> receptor agonist, Tyr<jats:sup>8<\/jats:sup>BK, administered at 0.25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup> i.p., significantly inhibited the eosinophil influx induced by LPS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The mechanism by which B<jats:sub>2<\/jats:sub> receptor agonists inhibit LPS\u2010induced eosinophil accumulation was investigated by pretreating the animals with indomethacin or a selective cyclooxygenase\u20102 inhibitor, NS\u2010398. Pretreatment with either indomethacin or NS\u2010398 had no effect on eosinophil influx induced by LPS alone, but those drugs were able to restore the LPS\u2010induced eosinophil influx in Tyr<jats:sup>8<\/jats:sup>BK (0.25\u2003nmol cavity<jats:sup>\u22121<\/jats:sup>) injected mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, endogenously generated bradykinin seems to modulate, through activation of B<jats:sub>2<\/jats:sub> receptors, eosinophil accumulation induced by LPS <jats:italic>via<\/jats:italic> a mechanism dependent on prostanoid synthesis.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 569\u2013575; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702567\">10.1038\/sj.bjp.0702567<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702567","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:03:49Z","timestamp":1106942629000},"page":"569-575","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bradykinin down\u2010regulates LPS\u2010induced eosinophil accumulation in the pleural cavity of mice through type 2\u2010kinin receptor activation: a role for prostaglandins"],"prefix":"10.1111","volume":"127","author":[{"given":"A R","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Larangeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Calixto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G M O","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P T","family":"Bozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H C","family":"Castro\u2010Faria\u2010Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4049\/jimmunol.156.1.269","article-title":"Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL\u20101\u03b2in vivo in the mouse","volume":"156","author":"AHLUWALIA A.","year":"1996","journal-title":"J. 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