{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:02:16Z","timestamp":1770501736635,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3530,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The purpose of this work was to verify the hypothesis that the rabbit ileum is a selective preparation for the NPY Y5 receptor by using new selective antagonists recently synthesized. Spontaneous contractions of the rabbit isolated ileum were recorded and binding experiments were performed in cells expressing the human NPY Y1, Y2, Y4 or Y5 receptor subtype.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>NPY analogues produced a concentration\u2010dependent transient inhibition of the spontaneous contractions of the rabbit ileum with the following order of potency hPP&gt;rPP&gt;PYY[Leu<jats:sup>31<\/jats:sup>,Pro<jats:sup>34<\/jats:sup>]\u2010NPY&gt;NPY&gt;&gt;NPY<jats:sub>13\u201336<\/jats:sub>. Pre\u2010exposure to rPP, PYY, [Leu<jats:sup>31<\/jats:sup>,Pro<jats:sup>34<\/jats:sup>]\u2010NPY or NPY (but not NPY<jats:sub>13\u201336<\/jats:sub>) inhibited the effect of subsequent administration of hPP suggesting cross\u2010desensitization of the preparation. The apparent affinity of the various agonists studied was correlated to the affinity reported for the human Y4 receptor subtype (and to a lesser extent for the rat Y4 subtype) but not to the affinity for the Y5 receptor subtype.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BIBO 3304, a selective NPY Y1 receptor antagonist, and CGP 71683A, a selective NPY Y5 receptor antagonist, did not affect the response to hPP. JCF 109, another NPY Y5 receptor antagonist, produced an inhibition of the response to hPP but only at the highest dose tested (10\u2003\u03bc<jats:sc>M<\/jats:sc>) which also, by itself, produced intrinsic inhibitory effects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>1229U91, a non\u2010selective ligand for Y1, Y2, Y4 and Y5 receptors with high affinity toward the Y1 and Y4 receptor subtypes, produced a concentration\u2010dependent transient inhibition of the spontaneous contractions of the rabbit ileum and a dose\u2010dependent inhibition of the response to hPP (apparent pK<jats:sub>B<\/jats:sub>: 7.2).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that in the rabbit ileum, the NPY receptor involved in the inhibition of the spontaneous contractile activity is a NPY Y4 receptor subtype.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 795\u2013801; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702594\">10.1038\/sj.bjp.0702594<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702594","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:04:34Z","timestamp":1106942674000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["NPY receptor subtype in the rabbit isolated ileum"],"prefix":"10.1111","volume":"127","author":[{"given":"Michel","family":"F\u00e9l\u00e9tou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Beauverger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Galizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A","family":"Boutin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Duhault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01057-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90257-9"},{"key":"e_1_2_7_4_1","first-page":"S16","article-title":"Reduction of food intake and body weight by a selective, non\u2010peptidic antagonist of the neuropeptide Y Y5 receptor subtype","volume":"22","author":"CRISCIONE L.","year":"1998","journal-title":"Obesity"},{"key":"e_1_2_7_5_1","unstructured":"DHANOA D.S. 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