{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:05:39Z","timestamp":1769814339918,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3500,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of the 5\u2010hydroxytryptamine (5\u2010HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)\u2010 or muscimol\u2010injected rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sibutramine dose\u2010dependently reduced feeding caused by food\u2010deprivation (ED<jats:sub>50<\/jats:sub>=5.1\u00b10.8\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED<jats:sub>50<\/jats:sub>=6.0\u00b10.5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1\u201310\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The hypophagic effect of 5.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> sibutramine in food\u2010deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non\u2010selective, 0.3 and 1.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), ritanserin (5\u2010HT<jats:sub>2A\/2C<\/jats:sub>, 0.5 and 1.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) and GR127935 (5\u2010HT<jats:sub>1B\/1D<\/jats:sub>, 0.5 and 1.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) did not modify the hypophagic effect of sibutramine, while SB206553 (5\u2010HT<jats:sub>2B\/2C<\/jats:sub>, 5 and 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) slightly but significantly reduced it (Fint(2.53)=3.4; <jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The reduction in food intake caused by 6.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> sibutramine in NPY\u2010injected rats was not modified by GR127935 (1.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that, with the possible exception of a partial involvement of 5\u2010HT<jats:sub>2B\/2C<\/jats:sub> receptors in sibutramine's hypophagia in food\u2010deprived rats, 5\u2010HT<jats:sub>1<\/jats:sub> and 5\u2010HT<jats:sub>2<\/jats:sub> receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2\u2003h after injection.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 1190\u20131194; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702633\">10.1038\/sj.bjp.0702633<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702633","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:16:44Z","timestamp":1106943404000},"page":"1190-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats"],"prefix":"10.1111","volume":"127","author":[{"given":"G","family":"Grignaschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Scagnol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Samanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90418-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(83)90447-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00134-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(93)90181-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01003-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1978.235.3.C97"},{"key":"e_1_2_7_8_1","first-page":"145","article-title":"Effects of metabolites 1 and 2 of sibutramine on the short\u2010term control of food intake in the rat","volume":"19","author":"FANTINO M.","year":"1995","journal-title":"Int. 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