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ATP\u2010induced inhibition was mediated by endothelium\u2010derived nitric oxide (EDNO) as the response was abolished by N<jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine (<jats:sc>L<\/jats:sc>\u2010NOARG; 10<jats:sup>\u22124<\/jats:sup>\u2003<jats:sc>M<\/jats:sc>), an inhibitor of nitric oxide synthase.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We conclude that ATP modulates lymphatic vasomotion by endothelium\u2010dependent and endothelium\u2010independent mechanisms. One of these is a dominant excitation caused through endothelial P<jats:sub>2<\/jats:sub> purinoceptors which because of an involvement of a pertussis toxin sensitive G\u2010protein may be of the P<jats:sub>2Y<\/jats:sub> receptor subtype. Their stimulation increases synthesis of phospholipase A<jats:sub>2<\/jats:sub> and production of thromboxane A<jats:sub>2<\/jats:sub>, an arachidonic acid metabolite which acts as an endothelium\u2010derived excitatory factor.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 1597\u20131602; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702710\">10.1038\/sj.bjp.0702710<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702710","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:21:01Z","timestamp":1106943661000},"page":"1597-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evidence that the ATP\u2010induced increase in vasomotion of guinea\u2010pig mesenteric lymphatics involves an endothelium\u2010dependent release of thromboxane A<sub>2<\/sub>"],"prefix":"10.1111","volume":"127","author":[{"given":"Jinnan","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyn E","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk F","family":"Van Helden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)00048-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1993.73.1.1","article-title":"Interstitial\u2010lymphatic mechanisms in the control of extracellular fluid volume","volume":"73","author":"AUCKLAND K.","year":"1993","journal-title":"Physiol. 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