{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:30:38Z","timestamp":1782955838693,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3469,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Central administration of bombesin inhibits gastric acid production independently of the centrally or peripherally\u2010acting stimuli employed. This study evaluates the role and location of the cerebral nitric oxide (NO) implicated in the inhibitory effect of central bombesin on <jats:italic>in vivo<\/jats:italic> rat gastric acid secretion, as induced by distension with 15\u2003cm H<jats:sub>2<\/jats:sub>O, insulin (0.75\u2003u.i.\u2003kg<jats:sup>\u22121<\/jats:sup> i.p.) TRH (1.2\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.c.) or pentagastrin (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The acid\u2010inhibitory effect of i.c. bombesin (40\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>) was prevented by prior administration of <jats:sc>L<\/jats:sc>\u2010NAME (80\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) in the dorsal motor nucleus of the vagus (DMN). This dose of <jats:sc>L<\/jats:sc>\u2010NAME when administered into the nucleus of the tractus solitarious (NTS) did not influence the effects of bombesin. Administration of <jats:sc>L<\/jats:sc>\u2010arginine (400\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) into the DMN restored the acid\u2010inhibitory effect of i.c. bombesin in animals treated with <jats:sc>L<\/jats:sc>\u2010NAME.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Microinjection of bombesin (12\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>) into the paraventricular nucleus of the hypothalamus (PvN) inhibits acid secretion stimulated by pentagastrin. This inhibitory effect was prevented by a previous injection of <jats:sc>L<\/jats:sc>\u2010NAME (80\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) into the DMN.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The release of NO in the DMN following i.c. administration of bombesin was confirmed by <jats:italic>in vivo<\/jats:italic> electrochemical detection.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Administration by microdialysis in the DMN of the NO\u2010donor SNAP (25\u2003m<jats:sc>M<\/jats:sc> in 1.5\u2003\u03bcl\u2003min<jats:sup>\u22121<\/jats:sup>) into the DMN inhibits pentagastrin\u2010stimulated gastric acid secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The present study suggests that nNOS\u2010containing neurons in the DMN have an inhibitory role in the control of gastric acid responses.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 1603\u20131610; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702717\">10.1038\/sj.bjp.0702717<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702717","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:21:01Z","timestamp":1106943661000},"page":"1603-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis of nitric oxide in the dorsal motor nucleus of the vagus mediates the inhibition of gastric acid secretion by central bombesin"],"prefix":"10.1111","volume":"127","author":[{"given":"Bel\u00e9n","family":"Beltr\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Dolores","family":"Barrachina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Quintero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan V","family":"Esplugues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb14898.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.1.R200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb23885.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1984.247.1.E41"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91000-Q"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14839"},{"key":"e_1_2_7_8_1","first-page":"R39","article-title":"Caudal brainstem systems mediate effects of bombesin\u2010like peptides on intake in rats","volume":"262","author":"FLYNN F.W.","year":"1992","journal-title":"Am. 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