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We investigated how the electrically stimulated release of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine from superfused rat striatal slices and its inhibition by carbachol are affected by specific inhibitors of voltage\u2010operated calcium channels of the L\u2010type (nifedipine), N\u2010type (\u03c9\u2010conotoxin GVIA) and P\/Q\u2010type (\u03c9\u2010agatoxin IVA).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The evoked release of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine was not diminished by nifedipine but was lowered by \u03c9\u2010conotoxin GVIA and by \u03c9\u2010agatoxin IVA, indicating that both the N\u2010 and the P\/Q\u2010type (but not the L\u2010type) channels are involved in the release. The N\u2010type channels were responsible for approximately two thirds of the release. The release was &gt;97% blocked when both \u03c9\u2010toxins acted together.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The inhibition of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine release by carbachol was not substantially affected by the blockade of the L\u2010 or P\/Q\u2010type channels. It was diminished but not eliminated by the blockade of the N\u2010type channels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In experiments on slices in which cholinesterases had been inhibited by paraoxon, inhibition of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine release by endogenous acetylcholine accumulating in the tissue could be demonstrated by the enhancement of the release after the addition of atropine. The inhibition was higher in slices with functional N\u2010type than with functional P\/Q\u2010type channels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We conclude that both the N\u2010 and the P\/Q\u2010type calcium channels contribute to the stimulation\u2010evoked release of acetylcholine in rat striatum, that the quantitative contribution of the N\u2010type channels is higher, and that the inhibitory muscarinic receptors are more closely coupled with the N\u2010type than with the P\/Q\u2010type calcium channels.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>127<\/jats:bold>, 1627\u20131632; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702721\">10.1038\/sj.bjp.0702721<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702721","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:21:01Z","timestamp":1106943661000},"page":"1627-1632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Calcium channels involved in the inhibition of acetylcholine release by presynaptic muscarinic receptors in rat striatum"],"prefix":"10.1111","volume":"127","author":[{"given":"Vladim\u00edr","family":"Dole\u017eal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Tu\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00210a003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01336.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00047-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.425bn.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.319bw.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00169-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175463"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1987.tb11239.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00969182"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701966"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1989.tb00779.x"},{"key":"e_1_2_6_13_1","first-page":"739","article-title":"Muscarinic receptor blockade increases basal acetylcholine release from striatal slices","volume":"252","author":"DOLE\u017eAL V.","year":"1990","journal-title":"J. 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