{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:46:35Z","timestamp":1771051595037,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3378,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Whole cell patch clamp techniques were used on thin brainstem slices to investigate the effects of 5\u2010hydroxytryptamine (5\u2010HT) on gastrointestinal\u2010projecting dorsal motor nucleus of the vagus (DMV) neurones. Neurones were identified as projecting to the stomach (<jats:italic>n<\/jats:italic>=122) or intestine (<jats:italic>n<\/jats:italic>=84) if they contained the fluorescent tracer Dil after it had been applied to the gastric fundus, corpus or antrum\/pylorus or to the duodenum or caecum.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A higher proportion of intestinal neurones (69%) than gastric neurones (47%) responded to 5\u2010HT with a concentration\u2010dependent inward current which was antagonized fully by the 5\u2010HT<jats:sub>2A<\/jats:sub> receptor antagonist ketanserin (1\u2003\u03bc<jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Stimulation of the nucleus tractus solitarius (NTS) induced inhibitory synaptic currents that were reduced in amplitude by application of the 5\u2010HT<jats:sub>1A<\/jats:sub> receptor agonist 8\u2010OHDPAT (1\u2003\u03bc<jats:sc>M<\/jats:sc>) or the 5\u2010HT<jats:sub>1A\/1B<\/jats:sub> receptor agonist TFMPP (1\u2003\u03bc<jats:sc>M<\/jats:sc>) in 61% and 52% of gastric\u2010 and intestinal\u2010projecting neurones, respectively. 5\u2010HT also significantly reduced the frequency but not the amplitude of spontaneous inhibitory currents.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data show that 5\u2010HT excites directly a larger proportion of intestinal projecting neurones than gastric\u2010projecting neurones, as well as inhibiting synaptic transmission from the NTS to the DMV. These data imply that the response to DMV neurones to 5\u2010HT may be determined and classified by their specific projections.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>128<\/jats:bold>, 1307\u20131315; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702908\">10.1038\/sj.bjp.0702908<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702908","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:25:43Z","timestamp":1106943943000},"page":"1307-1315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Characterization of the <i>in vitro<\/i> effects of 5\u2010hydroxytryptamine (5\u2010HT) on identified neurones of the rat dorsal motor nucleus of the vagus (DMV)"],"prefix":"10.1111","volume":"128","author":[{"given":"Kirsteen N","family":"Browning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Alberto","family":"Travagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15702.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830207"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040209"},{"key":"e_1_2_7_5_1","first-page":"930","article-title":"5\u2010hydroxytryptamine 4\u2010like receptors mediate the slow excitatory response to serotonin in the rat hippocampus","volume":"257","author":"ANDRADE R.","year":"1991","journal-title":"J. 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