{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:55:33Z","timestamp":1792112133915,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3378,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of S 15535 (4\u2010benzodioxan\u20105\u2010yl)1\u2010(indan\u20102\u2010yl)piperazine), an agonist at presynaptic and antagonist at postsynaptic 5\u2010HT<jats:sub>1A<\/jats:sub> receptors, on the impairment of spatial learning caused by intrahippocampal scopolamine in a two\u2010platform spatial discrimination task was studied.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Scopolamine (4.0\u2003\u03bcg\u2003\u03bcl<jats:sup>\u22121<\/jats:sup>), injected bilaterally into the CA1 region of the dorsal hippocampus 10\u2003min before each training session, impaired choice accuracy with no effect on choice latency and errors of omission.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Administered subcutaneously 30\u2003min before each training session, S 15535 1.0 (but not 0.3) mg\u2003kg<jats:sup>\u22121<\/jats:sup> did not modify choice accuracy but prevented its impairment by intrahippocampal scopolamine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>WAY 100635, a 5\u2010HT<jats:sub>1A<\/jats:sub> receptor antagonist, injected into the dorsal raphe at 1.0\u2003\u03bcg 0.5\u2003\u03bcl<jats:sup>\u22121<\/jats:sup> 5\u2003min before scopolamine, had no effect on choice accuracy and latency or errors of omission and did not modify the effect of scopolamine but completely antagonized the effect of S 15535 (1.0\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) on scopolamine\u2010induced impairment of choice accuracy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results confirm a previous report (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b4\">Carli <jats:italic>et al<\/jats:italic>., 1998<\/jats:ext-link>) that stimulation of presynaptic 5\u2010HT<jats:sub>1A<\/jats:sub> receptors in the dorsal raphe counteracts the deficit caused by intrahippocampal scopolamine, probably by facilitating the transfer of facilitatory information from the entorhinal cortex to the hippocampus.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Drugs that stimulate action on presynaptic 5\u2010HT<jats:sub>1A<\/jats:sub> receptors, such as S 15535 and other partial 5\u2010HT<jats:sub>1A<\/jats:sub> receptors agonists, may be useful in the symptomatic treatment of human memory disturbances associated with loss of cholinergic innervation to the hippocampus.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>128<\/jats:bold>, 1207\u20131214; 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