{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T21:02:16Z","timestamp":1752008536933},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3348,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>High salt diet is known to aggravate the vascular pathology in spontaneously hypertensive stroke\u2010prone rats (SHR\u2010SP). The aim of the present study was to assess the involvement of endothelial dysfunction in this effect. Contractile tension and membrane potential were simultaneously recorded in superior mesenteric artery rings of untreated and NaCl\u2010loaded (1% NaCl in the drinking water) SHR\u2010SP and normotensive Wistar Kyoto rats (WKY).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In unstimulated artery, hyperpolarization evoked by acetylcholine was not different in WKY and in NaCl\u2010loaded WKY; it was reduced in SHR\u2010SP and further reduced in NaCl\u2010loaded SHR\u2010SP. Hyperpolarization was unaffected by N<jats:sup>\u03c9<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine (<jats:sc>L<\/jats:sc>\u2010NA) but was abolished in high\u2010KCl solution.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In noradrenaline\u2010stimulated artery, ACh\u2010evoked hyperpolarization and relaxation were not different in WKY and in SHR\u2010SP. NaCl\u2010treatment did not affect the responses to ACh in WKY but decreased maximum relaxation in SHR\u2010SP from 93\u00b12% to 72\u00b17% of the contraction. In WKY, in NaCl\u2010loaded WKY and in SHR\u2010SP, <jats:sc>L<\/jats:sc>\u2010NA similarly shifted the concentration\u2010relaxation curve to ACh to the right and depressed its maximum but <jats:sc>L<\/jats:sc>\u2010NA did not affect the hyperpolarization to ACh. In NaCl\u2010loaded SHR\u2010SP, <jats:sc>L<\/jats:sc>\u2010NA blunted the effects of ACh on membrane potential and on contraction.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The NO donor SNAP abolished the depolarization and the contraction evoked by noradrenaline with the same potency in WKY and in untreated SHR\u2010SP but was more potent in NaCl\u2010loaded SHR\u2010SP.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In KCl\u2010contracted arteries the relaxations to ACh were not different in WKY and SHR\u2010SP but NaCl\u2010loaded SHR\u2010SP were more sensitive to ACh.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results showed that NaCl\u2010rich diet markedly reduced the <jats:sc>L<\/jats:sc>\u2010NA\u2010resistant responses to ACh and increased the sensitivity to NO in SHR\u2010SP.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (1999) <jats:bold>128<\/jats:bold>, 1513\u20131523; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702947\">10.1038\/sj.bjp.0702947<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0702947","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:28:56Z","timestamp":1106944136000},"page":"1513-1523","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of nitro\u2010<scp>L<\/scp>\u2010arginine on electrical and mechanical responses to acetylcholine in the superior mesenteric artery from stroke\u2010prone hypertensive rat"],"prefix":"10.1111","volume":"128","author":[{"given":"Philippe","family":"Ghisdal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9ophile","family":"Godfraind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199303000-00011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb03036.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3341"},{"issue":"11","key":"e_1_2_7_5_1","first-page":"S104","article-title":"Normalizing the expression of nitric oxide synthase by low\u2010dose AT1 receptor antagonism parallels improved vascular morphology in hypertensive rats","volume":"10","author":"BENNAI F.","year":"1999","journal-title":"J. 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