{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:12Z","timestamp":1787003772801,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3348,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>Effects of indomethacin, the selective cyclo\u2010oxygenase (COX)\u20102 inhibitors NS\u2010398 and DFU, and dexamethasone on gastric damage induced by 30\u2003min ischaemia followed by 60\u2003min reperfusion (I\u2010R) were investigated in rats. Modulation of gastric levels of COX\u20101 and COX\u20102 mRNA by I\u2010R was evaluated using Northern blot and reverse transcription\u2010polymerase chain reaction.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          I\u2010R\u2010induced gastric damage was dose\u2010dependently aggravated by administration of indomethacin (1\u201310\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ), NS\u2010398 (0.4\u20134\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ) or DFU (0.02\u20132\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ) as assessed macroscopically and histologically.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Likewise, administration of dexamethasone (1\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ) significantly increased I\u2010R damage.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Low doses of 16,16\u2010dimethyl\u2010prostaglandin(PG)E\n                          <jats:sub>2<\/jats:sub>\n                          , that did not protect against ethanol\u2010induced mucosal damage, reversed the effects of the selective COX\u20102 inhibitors, indomethacin and dexamethasone.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>I\u2010R had no effect on gastric COX\u20101 mRNA levels but increased COX\u20102 mRNA levels in a time\u2010dependent manner. Dexamethasone inhibited the I\u2010R\u2010induced expression of COX\u20102 mRNA.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          I\u2010R was not associated with a measurable increase in gastric mucosal formation of 6\u2010keto\u2010PGF\n                          <jats:sub>1\u03b1<\/jats:sub>\n                          and PGE\n                          <jats:sub>2<\/jats:sub>\n                          . PG formation was substantially inhibited by indomethacin (10\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ) but was not significantly reduced by NS\u2010398 (4\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ), DFU (2\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ) or dexamethasone (1\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          ).\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The findings indicate that selective COX\u20102 inhibitors and dexamethasone markedly enhance gastric damage induced by I\u2010R. Thus, whereas COX\u20102 has no essential role in the maintenance of gastric mucosal integrity under basal conditions, COX\u20102 is rapidly induced in a pro\u2010ulcerogenic setting and contributes to mucosal defence by minimizing injury. This suggests that in certain situations selective COX\u20102 inhibitors may have gastrotoxic effects.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>British Journal of Pharmacology<\/jats:italic>\n                    (1999)\n                    <jats:bold>128<\/jats:bold>\n                    , 1659\u20131666; doi:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0702966\">10.1038\/sj.bjp.0702966<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1038\/sj.bjp.0702966","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T15:29:41Z","timestamp":1106926181000},"page":"1659-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Selective cyclo\u2010oxygenase\u20102 inhibitors aggravate ischaemia\u2010reperfusion injury in the rat stomach"],"prefix":"10.1111","volume":"128","author":[{"given":"Nenad","family":"Maricic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Gretzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufina","family":"Schuligoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Respondek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitta M","family":"Peskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050362"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8966"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016651"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(83)90092-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00247.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1063"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90246-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.5.G955"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70095-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(94)90074-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(93)90018-S"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701673"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90660-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.14.4349"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00181-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12154-2"},{"key":"e_1_2_7_18_1","first-page":"H699","article-title":"Role of neutrophils in ischemia\u2010reperfusion\u2010induced microvascular injury","volume":"253","author":"HERNANDEZ L.A.","year":"1987","journal-title":"Am. 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