{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:50:31Z","timestamp":1777452631003,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effects of systemic, intrastriatal or intranigral administration of d\u2010amphetamine on glutamate, aspartate, ascorbic acid (AA), uric acid, dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5\u2010hydroxyindoleacetic acid (5\u2010HIAA) concentrations in dialysates from the striatum of freely\u2010moving rats were evaluated using microdialysis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>d\u2010Amphetamine (2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) given subcutaneously (s.c.) increased DA, AA and uric acid and decreased DOPAC+HVA, glutamate and aspartate dialysate concentrations over a 3\u2003h period after d\u2010amphetamine. 5\u2010HIAA concentrations were unaffected. Individual changes in glutamate and AA dialysate concentrations were negatively correlated.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>d\u2010Amphetamine (0.2\u2003m<jats:sc>M<\/jats:sc>), given intrastriatally, increased DA and decreased DOPAC+HVA and aspartate dialysate concentrations, but failed to change those of glutamate, AA uric acid or 5\u2010HIAA, over a 2\u2003h period after d\u2010amphetamine. Haloperidol (0.1\u2003m<jats:sc>M<\/jats:sc>), given intrastriatally, increased aspartate concentrations without affecting those of glutamate or AA.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>d\u2010Amphetamine (0.2\u2003m<jats:sc>M<\/jats:sc>), given intranigrally, increased AA and uric acid dialysate concentrations and decreased those of glutamate, aspartate and DA; DOPAC+HVA and 5\u2010HIAA concentrations were unaffected.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that d\u2010amphetamine\u2010induced increases in AA and uric acid and decreases in glutamate concentrations are triggered at nigral sites. The changes in aspartate levels may be evoked by at least two mechanisms: striatal (mediated by inhibitory dopaminergic receptors) and nigral (activation of amino acid carrier\u2010mediated uptake).<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 582\u2013588; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703066\">10.1038\/sj.bjp.0703066<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703066","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:41:22Z","timestamp":1106944882000},"page":"582-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["On the mechanism of d\u2010amphetamine\u2010induced changes in glutamate, ascorbic acid and uric acid release in the striatum of freely moving rats"],"prefix":"10.1111","volume":"129","author":[{"given":"Maddalena","family":"Miele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A","family":"Mura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Enrico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier A","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Migheli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Zangani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egidio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S","family":"Desole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90204-U"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00033-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00507-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91731-F"},{"key":"e_1_2_7_6_1","first-page":"127","volume-title":"Monitoring Molecules in Neuroscience","author":"CHIUEH C.C.","year":"1994"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90285-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-6989(87)90083-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90850-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1997.0193"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66041726.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-01979.1998"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01334-E"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(94)00027-F"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90379-P"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1523\/JNEUROSCI.16-01-00055.1996","article-title":"Components of glial response to exogenous and synaptic glutamate in rat hippocampal microcultures","volume":"16","author":"MENNERICK S.","year":"1996","journal-title":"J. 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