{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:15:01Z","timestamp":1790867701391,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>\u03b2\u2010adrenoceptor\u2010mediated relaxation was investigated in ring preparations of rat isolated thoracic aorta. Rings were pre\u2010constricted with a sub\u2010maximal concentration of noradrenaline (1\u2003\u03bc<jats:sc>M<\/jats:sc>) and relaxant responses to cumulative concentrations of \u03b2\u2010adrenoceptor agonists obtained.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The concentration\u2010response curve (CRC) to isoprenaline was shifted to the right by propranolol (0.3\u2003\u03bc<jats:sc>M<\/jats:sc>) with a steepening of the slope. Estimation of the magnitude of the shift from EC<jats:sub>50<\/jats:sub> values gave a pA<jats:sub>2<\/jats:sub> of 7.6. Selective \u03b2<jats:sub>1<\/jats:sub>\u2010 and \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonists, CGP 20712A (0.1\u2003\u03bc<jats:sc>M<\/jats:sc>) and ICI 118551 (0.1\u2003\u03bc<jats:sc>M<\/jats:sc>), respectively, produced 4 and 14 fold shifts of the isoprenaline CRC.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Atypical \u03b2\u2010adrenoceptor agonists also produced concentration\u2010dependent relaxation of aortic rings. The order of potency of the \u03b2\u2010adrenoceptor agonists was (\u2212log EC<jats:sub>50<\/jats:sub>): isoprenaline (6.25)&gt;cyanopindolol (5.59)&gt;isoprenaline+propranolol (5.11)&gt;CGP 12177A (4.40)&gt;ZD 2079 (4.24)&gt;ZM 215001 (4.07)&gt;BRL 37344 (3.89). Relaxation to CGP 12177A and ZM 215001 was unaffected by propranolol (0.3\u2003\u03bc<jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SR 59230A (1\u2003\u03bc<jats:sc>M<\/jats:sc>) and cyanopindolol (1\u2003\u03bc<jats:sc>M<\/jats:sc>), \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptor antagonists, had no effect on the isoprenaline (in the presence of propranolol) or CGP 12177A CRCs. Bupranolol and CGP 20712A, at \u03bc<jats:sc>M<\/jats:sc> concentrations (\u03b2<jats:sub>4<\/jats:sub>\u2010adrenceptor antagonists), inhibited responses to isoprenaline (in the presence of propranolol) and CGP 12177A.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, atypical \u03b2\u2010adrenoceptors co\u2010exist with \u03b2<jats:sub>1<\/jats:sub>\u2010 and \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors in rat aorta. Although non\u2010conventional partial agonists and selective \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptor agonist cause relaxation, the vascular atypical \u03b2\u2010adrenoceptor does not appear to correspond to the \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptor. There are, however, similarities with the putative \u03b2<jats:sub>4<\/jats:sub>\u2010adrenoceptor.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 637\u2013644; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703091\">10.1038\/sj.bjp.0703091<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703091","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:46:01Z","timestamp":1106945161000},"page":"637-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["<i>\u03b2<\/i><sub>1<\/sub>\u2010, <i>\u03b2<\/i><sub>2<\/sub>\u2010 and atypical <i>\u03b2<\/i>\u2010adrenoceptor\u2010mediated relaxation in rat isolated aorta"],"prefix":"10.1111","volume":"129","author":[{"given":"L","family":"Brawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19890032"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/309163a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610130604"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13167.x"},{"key":"e_1_2_7_6_1","first-page":"242","article-title":"Interaction of dihydroalprenolol and cyanopindolol with atypical \u03b2\u2010adrenoceptors in guinea\u2010pig ileum","volume":"96","author":"BLUE D.R.","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_7_1","first-page":"395","article-title":"Influence of L\u2010NAME and removal of endothelium on noradrenaline contraction and isoprenaline relaxation in rat isolated thoracic aorta","volume":"122","author":"BRAWLEY L.","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_8_1","first-page":"18","article-title":"Role of endothelium in classical and atypical \u03b2\u2010adrenoceptor\u2010mediated vasorelaxation in rat isolated aorta","volume":"125","author":"BRAWLEY L.","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.35.6.835"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501307"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701523"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118823"},{"key":"e_1_2_7_13_1","first-page":"213","article-title":"Zeneca ZD2079 is a novel \u03b23\u2010adrenoceptor agonist","volume":"112","author":"GRANT T.L.","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14507.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15248.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90065-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15159.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15648.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1996.tb00424.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/214597a0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90492-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.1999.00128.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.1999.00121.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1987.tb01508.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15285.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701516"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15209.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14122.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb09792.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2610401"},{"key":"e_1_2_7_31_1","first-page":"733","article-title":"Beta\u20101 and Beta\u20102 adrenoceptor \u2010mediated responses in preparations of pulmonary artery and aorta from young and aged rats","volume":"228","author":"O'DONNELL S.R.","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_32_1","first-page":"227","article-title":"Responses to the \u03b22\u2010selective agonist procaterol of vascular and atrial preparations with different functional \u03b2\u2010adrenoceptor populations","volume":"84","author":"O'DONNELL S.R.","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17049.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00076-3"},{"key":"e_1_2_7_35_1","first-page":"22","article-title":"An atypical \u03b2\u2010adrenoceptor mediates relaxation of the rat isolated mesenteric artery","volume":"114","author":"SOOCH S.","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_36_1","first-page":"261","article-title":"Evidence for atypical \u03b2\u2010adrenoceptors in rat vasculature","volume":"117","author":"SOOCH S.","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48178.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1016\/S0021-9258(18)32689-9","article-title":"CGP 12177 A hydrophilic \u03b2\u2010adrenergic radioligand reveals high affinity binding of agonists to intact cells","volume":"258","author":"STAEHELIN M.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9047"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13028.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90007-4"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0703091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T17:47:13Z","timestamp":1698601633000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0703091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.1038\/sj.bjp.0703091"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0703091","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"2009-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}