{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T16:20:42Z","timestamp":1774455642630,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The role of cyclo\u2010oxygenase\u20101 (COX\u20101) and cyclo\u2010oxygenase\u20102 (COX\u20102) in the upper urinary tract of the guinea\u2010pig and rat was examined using simultaneous tension recordings of the proximal and distal regions of the renal pelvis and the ureter.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The guinea\u2010pig upper urinary tract contracted at a frequency (7.52\u00b10.3\u2003min<jats:sup>\u22121<\/jats:sup> at 35\u00b0C) significantly lower than the frequency in the proximal renal pelvis (21.6\u00b11.3\u2003min<jats:sup>\u22121<\/jats:sup>) and in the distal renal pelvis and ureter (20.2\u00b11.4\u2003min<jats:sup>\u22121<\/jats:sup>) of the rat (at 30\u00b0C).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Indomethacin (1\u2003\u03bc<jats:sc>M<\/jats:sc> for 60\u2003min), decreased the motility index (amplitude\u00d7frequency) (MI) in all three regions of the guinea\u2010pig upper urinary tract, an effect which mainly arose from a decrease in the frequency of contractions. In the rat, indomethacin (1\u201330\u2003\u03bc<jats:sc>M<\/jats:sc> for 60\u2003min) significantly decreased the MI calculated in the proximal renal pelvis (30\u2003\u03bc<jats:sc>M<\/jats:sc> indomethacin), and in the distal renal pelvis (10\u2003\u03bc<jats:sc>M<\/jats:sc> indomethacin), arising from a significant decrease in the amplitude of contractions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The COX\u20101 inhibitor, valeryl salicylate (VSA) (5\u2013100\u2003\u03bc<jats:sc>M<\/jats:sc> for 60\u2003min), had no effect on either the amplitude or frequency of contractions in the guinea\u2010pig upper urinary tract. In contrast, VSA increased the force of contractions in the proximal and distal renal pelvis of the rat, whilst having little effect on the frequency of contractions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The COX\u20102 inhibitor, NS\u2010398 (10\u2013100\u2003n<jats:sc>M<\/jats:sc> for 60\u2003min) reduced the MI in the guinea\u2010pig upper urinary tract in a concentration\u2010dependent manner. The MIs calculated for the proximal renal pelvis, distal renal pelvis and ureter, were decreased by 72, 64 and 72% respectively, in 100\u2003n<jats:sc>M<\/jats:sc> NS\u2010398. NS\u2010398 (10\u2013100\u2003n<jats:sc>M<\/jats:sc>) had no effect on any of the three parameters measured in either the proximal or distal renal pelvis of the rat.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data suggest that endogenously\u2010released prostaglandins (PGs) maintain the myogenic contractility of the upper urinary tract in both the guinea\u2010pig and rat. Moreover COX\u20102 is the primary enzyme involved in synthesizing PGs in the guinea\u2010pig upper urinary tract, while COX\u20101 appears to be the predominantly active enzyme in the rat.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 661\u2013670; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703104\">10.1038\/sj.bjp.0703104<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703104","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:46:01Z","timestamp":1106945161000},"page":"661-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effects of selective inhibitors of cyclo\u2010oxygenase\u20101 (COX\u20101) and cyclo\u2010oxygenase\u20102 (COX\u20102) on the spontaneous myogenic contractions in the upper urinary tract of the guinea\u2010pig and rat"],"prefix":"10.1111","volume":"129","author":[{"given":"M E","family":"Davidson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1975.tb04075.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172118"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365598509180267"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1130"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1139\/y95-215"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11202"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90396-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02244.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(94)90074-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(93)90018-S"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00592794"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1128(199603)16:2<181::AID-MED3>3.0.CO;2-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(95)00194-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91596-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-05411.1995"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1139\/y75-035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690211"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/y83-180"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37819-9"},{"key":"e_1_2_7_21_1","first-page":"228","article-title":"Renorenal Reflexes: role of substance P and prostaglandins","volume":"8","author":"KOPP U.C.","year":"1993","journal-title":"NIPS"},{"key":"e_1_2_7_22_1","first-page":"R1513","article-title":"Inhibitory renorenal reflexes: a role for renal prostaglandins in activation of renal sensory receptors","volume":"261","author":"KOPP U.C.","year":"1991","journal-title":"Am. 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