{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:27:14Z","timestamp":1777454834419,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>This study examined whether activation of group II metabotropic glutamate (mGlu) receptors in the substantia nigra pars reticulata (SNr) could reverse akinesia in a rodent model of Parkinson's disease (PD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Male Sprague Dawley rats, stereotaxically cannulated above either the SNr or third ventricle, were rendered akinetic by injection of reserpine (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> s.c.). Eighteen hours later, the rotational behaviour induced by unilateral injection of the group II mGlu receptor agonist, (2S,2\u2032R,3\u2032R)\u20102\u2010(2\u2032,3\u2032\u2010dicarboxycyclopropyl)glycine (DCG\u2010IV), was examined.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Following intranigral injection, DCG\u2010IV (0.125\u20130.75\u2003nmol in 0.1\u2003\u03bcl) produced a dose\u2010dependent increase in net contraversive rotations (<jats:italic>n<\/jats:italic>=6\u20138 animals per dose), reaching a maximum of 395\u00b151 rotations 60\u2003min<jats:sup>\u22121<\/jats:sup> after 0.75\u2003nmol. The effects of DCG\u2010IV (0.5\u2003nmol) were inhibited by 63.0\u00b19.0% following 30\u2003min pre\u2010treatment with the group II mGlu receptor antagonist, (2S)\u2010\u03b1\u2010ethylglutamic acid (EGLU; 100\u2003nmol in 0.2\u2003\u03bcl; <jats:italic>n<\/jats:italic>=6).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Following intraventricular injection, DCG\u2010IV (0.125\u20131.5\u2003nmol in 2\u2003\u03bcl) produced a dose\u2010dependent increase in bilateral locomotor activity (<jats:italic>n<\/jats:italic>=6\u20137 animals per dose), reaching a maximum of 180\u00b121 locomotor units 30\u2003min<jats:sup>\u22121<\/jats:sup> after 0.5\u2003nmol. Pre\u2010treatment with EGLU (200\u2003nmol in 2\u2003\u03bcl) inhibited the effects of DCG\u2010IV (0.5\u2003nmol) by 68.2\u00b112.3% (<jats:italic>n<\/jats:italic>=5).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data show that activation of group II mGlu receptors in the SNr provides relief of akinesia in the reserpinized rat model of PD. The reversal seen following intraventricular administration supports the likely therapeutic benefit of systemically\u2010active group II mGlu receptor agonists in PD.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 541\u2013546; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703105\">10.1038\/sj.bjp.0703105<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703105","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:41:22Z","timestamp":1106944882000},"page":"541-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["The group II metabotropic glutamate receptor agonist, DCG\u2010IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine\u2010treated rat"],"prefix":"10.1111","volume":"129","author":[{"given":"Lee","family":"Dawson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Chadha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Megalou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Duty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00442-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00505.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2402638"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90173-A"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7092"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.205"},{"key":"e_1_2_7_8_1","first-page":"60P","article-title":"Locomotor effects following injection of the group II mGluR agonist, DCG\u2010IV, into the substantia nigra pars reticulata of the reserpine\u2010treated rat model of Parkinson's disease","volume":"126","author":"DAWSON L.","year":"1999","journal-title":"Br. 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