{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:12:53Z","timestamp":1760440373809},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":3229,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>In the rat hepatic artery, the SK<jats:sub>Ca<\/jats:sub> inhibitors UCL 1684 (300\u2003n<jats:sc>M<\/jats:sc>) completely blocked, and scyllatoxin (1\u2003\u03bc<jats:sc>M<\/jats:sc>) and d\u2010tubocurarine (100\u2003\u03bc<jats:sc>M<\/jats:sc>) partially inhibited EDHF relaxations when each of them was combined with charybdotoxin (300\u2003n<jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The IK<jats:sub>Ca<\/jats:sub> inhibitors clotrimazole (3\u2003\u03bc<jats:sc>M<\/jats:sc>) and 2\u2010chlorophenyl\u2010bisphenyl\u2010methanol (3\u2003\u03bc<jats:sc>M<\/jats:sc>) strongly depressed EDHF relaxations when each of them was combined with apamin (300\u2003n<jats:sc>M<\/jats:sc>). The cytochrome P450 mono\u2010oxygenase inhibitor ketoconazole (10\u2003\u03bc<jats:sc>M<\/jats:sc>) had no effect in the presence of apamin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ciclazindol (10\u2003\u03bc<jats:sc>M<\/jats:sc>), which abolishes EDHF relaxations in the presence of apamin, almost completely prevented the calcium ionophore (A23187) stimulated <jats:sup>86<\/jats:sup>Rb<jats:sup>+<\/jats:sup> influx <jats:italic>via<\/jats:italic> the Gardos channel (IK<jats:sub>Ca<\/jats:sub>) in human erythrocytes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase inhibitor ouabain (500\u2003\u03bc<jats:sc>M<\/jats:sc>) and the K<jats:sub>IR<\/jats:sub> blocker Ba<jats:sup>2+<\/jats:sup> (30\u2003\u03bc<jats:sc>M<\/jats:sc>) neither alone nor in combination inhibited EDHF relaxations. Ba<jats:sup>2+<\/jats:sup> was also without effect in the presence of either apamin or charybdotoxin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In contrast to EDHF, an increase in extracellular [K<jats:sup>+<\/jats:sup>] from 4.6\u2003m<jats:sc>M<\/jats:sc> to 9.6, 14.6 and 19.6\u2003m<jats:sc>M<\/jats:sc> inconsistently relaxed arteries. In K<jats:sup>+<\/jats:sup>\u2010free physiological salt solution, re\u2010admission of K<jats:sup>+<\/jats:sup> always caused complete and sustained relaxations which were abolished by ouabain but unaffected by Ba<jats:sup>2+<\/jats:sup>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The present study provides pharmacological evidence for the involvement of SK<jats:sub>Ca<\/jats:sub> and IK<jats:sub>Ca<\/jats:sub> in the action of EDHF in the rat hepatic artery. Our results are not consistent with the idea that EDHF is K<jats:sup>+<\/jats:sup> activating Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ATPase and K<jats:sub>IR<\/jats:sub> in this blood vessel.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 1490\u20131496; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703226\">10.1038\/sj.bjp.0703226<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703226","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:35:19Z","timestamp":1106944519000},"page":"1490-1496","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of inhibitors of small\u2010 and intermediate\u2010conductance calcium\u2010activated potassium channels, inwardly\u2010rectifying potassium channels and Na<sup>+<\/sup>\/K<sup>+<\/sup> ATPase on EDHF relaxations in the rat hepatic artery"],"prefix":"10.1111","volume":"129","author":[{"given":"David A","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M","family":"Zygmunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouya","family":"Movahed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas L G","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D","family":"H\u00f6gest\u00e4tt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"9P","article-title":"Pharmacological evidence for the involvement of IKCa and SKCa in EDHF\u2010mediated relaxation of the rat hepatic artery","volume":"125","author":"ANDERSSON D.A.","year":"1998","journal-title":"Br. 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