{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:35:16Z","timestamp":1789803316647,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3226,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The actions of lignocaine and benzocaine on transient and late Na<jats:sup>+<\/jats:sup> current generated by large diameter (50\u2003\u03bcm) adult rat dorsal root ganglion neurones, were studied using patch\u2010clamp techniques.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Both drugs blocked whole\u2010cell late Na<jats:sup>+<\/jats:sup> current in a concentration\u2010dependent manner. At 200\u2003ms following the onset of a clamp step from \u2212110 to \u221240\u2003mV, the apparent <jats:italic>K<\/jats:italic> for block of late Na<jats:sup>+<\/jats:sup> current by lignocaine was 57.8\u00b115\u2003\u03bc<jats:sc>M<\/jats:sc> (mean\u00b1s.e.mean, <jats:italic>n<\/jats:italic>=4). The value for benzocaine was 24.9\u00b13.3\u2003\u03bc<jats:sc>M<\/jats:sc>, (mean\u00b1s.e.mean, <jats:italic>n<\/jats:italic>=3).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effect of lignocaine on transient current, in randomly selected neurones, appeared variable (<jats:italic>n<\/jats:italic>=8, half\u2010block from \u223c50 to 400\u2003\u03bc<jats:sc>M<\/jats:sc>). Half\u2010block by benzocaine was not attained, but both whole\u2010cell (<jats:italic>n<\/jats:italic>=11) and patch data suggested a high apparent <jats:italic>K<\/jats:italic>,&gt;250\u2003\u03bc<jats:sc>M<\/jats:sc>. Transient current always remained after late current was blocked.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The voltage\u2010dependence of residual late current steady\u2010state inactivation was not shifted by 20\u2003\u03bc<jats:sc>M<\/jats:sc> benzocaine (<jats:italic>n<\/jats:italic>=3), whereas 200\u2003\u03bc<jats:sc>M<\/jats:sc> benzocaine shifted the voltage\u2010dependence of transient current steady\u2010state inactivation by \u221218.7\u00b15.9\u2003mV (mean\u00b1s.e.mean, <jats:italic>n<\/jats:italic>=4).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In current\u2010clamp, benzocaine (250\u2003\u03bc<jats:sc>M<\/jats:sc>) could block subthreshold, voltage\u2010dependent inward current, increasing the threshold for eliciting action potentials, without preventing their generation (<jats:italic>n<\/jats:italic>=2).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Block of late Na<jats:sup>+<\/jats:sup> current by systemic local anaesthetic may play a part in preventing ectopic impulse generation in sensory neurones.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 1617\u20131626; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703261\">10.1038\/sj.bjp.0703261<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703261","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:38:28Z","timestamp":1106944708000},"page":"1617-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Selective block of late Na<sup>+<\/sup> current by local anaesthetics in rat large sensory neurones"],"prefix":"10.1111","volume":"129","author":[{"given":"Mark D","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/379257a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-02-00660.1993"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019178"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.3.1503"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.5.2538"},{"key":"e_1_2_7_7_1","first-page":"123","article-title":"Selective block of persistent Na+ current by lidocaine in cultured rat sensory neurones","volume":"511","author":"BAKER M.D.","year":"1998","journal-title":"J. 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