{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T17:33:33Z","timestamp":1720978413412},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":3226,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>It has been proposed that the vagus nerve plays a role in mediating cholecystokinin\u20108 (CCK\u20108) effect on such gastric functions as motility, emptying and gastric acid secretion. To examine the contribution of the efferent pathways in realizing these effects, efferent mass activity in the ventral gastric vagal nerve in Sprague\u2010Dawley rats was recorded.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intravenous infusion of CCK\u20108 (0.1\u20131\u2003nmol) suppressed the efferent activity. The effect of CCK\u20108 was significantly reduced in animals with total subdiaphragmatic vagotomy in comparison to those with partial vagotomy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intravenous infusion of CCK<jats:sub>A<\/jats:sub> receptor antagonist L\u2010364,718 (1\u2013100\u00d710<jats:sup>\u22126<\/jats:sup> g) blocked the response of vagal efferent activity to 0.1\u2003nmol CCK\u20108, but the CCK<jats:sub>B<\/jats:sub> receptor antagonist L\u2010365,260 (1\u2013100\u00d710<jats:sup>\u22126<\/jats:sup> g) did not in the conditions of either partial or total vagotomy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intracisternal infusion of L\u2010364,718 (1\u00d710<jats:sup>\u22126<\/jats:sup> g) blocked the response of vagal efferent activity to 0.1\u2003nmol CCK\u20108 i.v.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Infusion of exogenous CCK\u20108 did not affect the activity of supradiaphragmatic vagal afferents.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that the effect of systemically administered CCK\u20108 on vagal efferent activity is mediated by both peripherally (subdiaphragmatically) and centrally localized CCK<jats:sub>A<\/jats:sub> receptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>129<\/jats:bold>, 1649\u20131654; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703270\">10.1038\/sj.bjp.0703270<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703270","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:38:28Z","timestamp":1106944708000},"page":"1649-1654","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exogenous cholecystokinin\u20108 reduces vagal efferent nerve activity in rats through CCK<sub>A<\/sub> receptors"],"prefix":"10.1111","volume":"129","author":[{"given":"Violeta","family":"Bucinskaite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieko","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lundeberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(94)00129-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1152\/jn.1993.70.6.2584","article-title":"Cholecystokinin\u2010gated currents in neurons of the rat solitary complex in vitro","volume":"70","author":"BRANCHEREAU P.","year":"1993","journal-title":"J. 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