{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:29:32Z","timestamp":1790882972249,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3195,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>This study investigates the role of adrenal\u2010derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)\u20104 inhibitor, of pulmonary eosinophilia and airway hyperresponsiveness (AHR) in allergic mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The following experimental groups were studied in mice sensitized and challenged with ovalbumin (OVA): normal, adrenalectomized, propranolol (\u03b2\u2010adrenoceptor antagonist) and metyrapone (corticosterone synthesis inhibitor) treated. These interventions were studied both in the absence and in the presence of rolipram. Eosinophil numbers in the bronchoalveolar lavage (BAL) and AHR to methacholine were measured 24\u2003h after OVA challenge.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Treatment of sensitized mice with rolipram (0.3\u201310\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.), inhibited pulmonary eosinophilia and the AHR to methacholine in OVA\u2010challenged mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Adrenalectomy increased the number of eosinophils in the BAL of OVA\u2010challenged mice but had no effect on AHR to methacholine. Adrenalectomy attenuated both the rolipram\u2010induced inhibition of BAL eosinophilia and AHR to methacholine in OVA challenged mice. Propranolol (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) had no effect on the inhibition of eosinophilia by rolipram but attenuated the inhibition of AHR to methacholine in OVA challenged mice. On the other hand, metyrapone (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.) attenuated the inhibition of eosinophilia by rolipram but had no effect on the inhibition of AHR to methacholine in OVA challenged mice. Metyrapone\u2010treatment alone increased the number of eosinophils in the BAL of OVA\u2010challenged mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results identify an important role for adrenal\u2010derived catecholamines and corticosterone on the inhibition of pulmonary eosinophilia and AHR by rolipram in allergic mice.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 457\u2013463; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703308\">10.1038\/sj.bjp.0703308<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703308","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:53:27Z","timestamp":1106945607000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines"],"prefix":"10.1111","volume":"130","author":[{"given":"T T","family":"Kung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Kreutner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R W","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"384","article-title":"Anti\u2010inflammatory activity of inhaled mometasone furoate in allergic mice","volume":"48","author":"CHAPMAN R.W.","year":"1998","journal-title":"Arzneim.-Forsch. 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