{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:31:22Z","timestamp":1790800282229,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>By mobilizing histamine in response to gastrin, the ECL cells in the oxyntic mucosa play a key role in the control of the parietal cells and hence of gastric acid secretion. General anaesthesia suppresses basal and gastrin\u2010 and histamine\u2010stimulated acid secretion. The present study examines if the effect of anaesthesia on basal and gastrin\u2010stimulated acid secretion is associated with suppressed ECL\u2010cell histamine secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A microdialysis probe was implanted in the submucosa of the ventral aspect of the acid\u2010producing part of the stomach (32 rats). Three days later, ECL\u2010cell histamine mobilization was monitored 2\u2003h before and 4\u2003h after the start of intravenous infusion of gastrin (5\u2003nmol\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003h<jats:sup>\u22121<\/jats:sup>). The rats were either conscious or anaesthetized. Four commonly used anaesthetic agents were given 1\u2003h before the start of the experiments by intraperitoneal injection: chloral hydrate (300\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), pentobarbitone (40\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), urethane (1.5\u2003g\u2003kg<jats:sup>\u22121<\/jats:sup>) and a mixture of fluanisone\/fentanyl\/midazolam (15\/0.5\/7.5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In a parallel series of experiments, basal\u2010 and gastrin\u2010induced acid secretion was monitored in six conscious and 25 anaesthetized (see above) chronic gastric fistula rats. All anaesthetic agents lowered gastrin\u2010stimulated acid secretion; also the basal acid output was reduced (fluanisone\/fentanyl\/midazolam was an exception).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Anaesthesia reduced gastrin\u2010stimulated but not basal histamine release by 55\u201380%. The reduction in gastrin\u2010induced acid response (70\u201395%) was strongly correlated to the reduction in gastrin\u2010induced histamine mobilization. The correlation is in line with the view that the reduced acid response to gastrin reflects impaired histamine mobilization.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Rat stomach ECL cells were purified by counter\u2010flow elutriation. Gastrin\u2010evoked histamine mobilization from the isolated ECL cells was determined in the absence or presence of anaesthetic agents in the medium. With the exception of urethane, they inhibited gastrin\u2010evoked histamine secretion dose\u2010dependently, indicating a direct effect on the ECL cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Anaesthetized rats are widely used to study acid secretion and ECL\u2010cell histamine release. The present results illustrate the short\u2010comings of such an approach in that a number of anaesthetic agents were found to impair not only acid secretion but also the secretion of ECL\u2010cell histamine \u2013 some acting in a direct manner.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 725\u2013730; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703347\">10.1038\/sj.bjp.0703347<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703347","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:14:42Z","timestamp":1106946882000},"page":"725-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Anaesthetic agents inhibit gastrin\u2010stimulated but not basal histamine release from rat stomach ECL cells"],"prefix":"10.1111","volume":"130","author":[{"given":"P","family":"Norl\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"H\u00e5kanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609031622"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381874"},{"key":"e_1_2_6_4_1","first-page":"G1243","article-title":"Role of gastrin\/CCK\u2010B receptors in meal\u2010stimulated acid secretion in rats","volume":"272","author":"AURANG K.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_5_1","first-page":"51","article-title":"Influence of some anaesthetics on pharmacologically stimulated gastric secretion in rats","volume":"28","author":"BARRET A.M.","year":"1978","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199512000-00013"},{"key":"e_1_2_6_7_1","first-page":"5","article-title":"Nouvelle technique de fistule gastrique chronique chez le rat","author":"BEL A.","year":"1966","journal-title":"J. Med. Lyon"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90937-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90056-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1003835905939"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90083-B"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108998614"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492340"},{"key":"e_1_2_6_14_1","first-page":"1171","volume-title":"Physiology of the Gastrointestinal Tract","author":"H\u00c5KANSON R.","year":"1994"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00008-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75840-9_19"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007494"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00340-9"},{"key":"e_1_2_6_19_1","first-page":"181","article-title":"Modulation by endogenous nitric oxide of acid secretion induced by gastric distension in rats: Enhancement by nitric oxide synthase inhibitor","volume":"291","author":"KITAMURA M.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00096-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1152\/ajplegacy.1967.213.5.1331","article-title":"Effect of anesthetic agents on maximal histamine\u2010induced gastric secretion in Shay rats","volume":"213","author":"LEE Y.H.","year":"1967","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(97)01018-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1995.tb09980.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90719-S"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991918"},{"key":"e_1_2_6_26_1","first-page":"G40","article-title":"Modulation of histamine release from canine fundic mucosal mast cells","volume":"254","author":"SOLL A.H.","year":"1988","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.6.698"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.44.63"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90952-W"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0703347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T15:16:57Z","timestamp":1698592617000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0703347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1038\/sj.bjp.0703347"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0703347","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}