{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:31:57Z","timestamp":1789943517767,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Cholinergic neurons were identified in rat striatal slices by their size, membrane properties, sensitivity to the NK<jats:sub>1<\/jats:sub> receptor agonist (Sar<jats:sup>9<\/jats:sup>, Met(O<jats:sub>2<\/jats:sub>)<jats:sup>11<\/jats:sup>) Substance P, and expression of choline acetyltransferase mRNA. A<jats:sub>1<\/jats:sub> receptor mRNA was detected in 60% of the neurons analysed, and A<jats:sub>2A<\/jats:sub> receptor mRNA in 67% (<jats:italic>n<\/jats:italic>=15).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>1<\/jats:sub> receptor agonist R\u2010N<jats:sup>6<\/jats:sup>\u2010(2\u2010phenylisopropyl)adenosine (R\u2010PIA) hyperpolarized cholinergic neurons in a concentration dependent manner sensitive to the A<jats:sub>1<\/jats:sub> antagonist 8\u2010cyclopentyl\u20101,3\u2010dipropylxanthine (DPCPX, 100\u2003n<jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In dual stimulus experiments, the A<jats:sub>2A<\/jats:sub> receptor antagonist 8\u2010(3\u2010chlorostyryl)caffeine (CSC, 500\u2003n<jats:sc>M<\/jats:sc>) decreased release of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine from striatal slices (S2\/S1 0.78\u00b10.07 versus 0.95\u00b10.05 in control), as did adenosine deaminase (S2\/S1 ratio 0.69\u00b10.05), whereas the A<jats:sub>1<\/jats:sub> receptor antagonist DPCPX (100\u2003n<jats:sc>M<\/jats:sc>) had no effect (S2\/S1 1.05\u00b10.14).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the presence of adenosine deaminase the adenosine A<jats:sub>2A<\/jats:sub> receptor agonist 2\u2010p\u2010((carboxyethyl)phenylethylamino)\u20105\u2032\u2010N\u2010ethylcarboxamidoadenosine (CGS21680, 10\u2003n<jats:sc>M<\/jats:sc>) increased release (S2\/S1 ratio 1.03\u00b10.05 versus 0.88\u00b10.05 in control), an effect blocked by the antagonist CSC (500\u2003n<jats:sc>M<\/jats:sc>, S2\/S1 0.68\u00b10.05, versus 0.73\u00b10.08 with CSC alone). The combined superfusion of bicuculline (10\u2003\u03bc<jats:sc>M<\/jats:sc>), saclofen (1\u2003\u03bc<jats:sc>M<\/jats:sc>) and naloxone (10\u2003\u03bc<jats:sc>M<\/jats:sc>) had no effect on the stimulation by CGS21680 (S2\/S1 ratio 0.99\u00b10.04).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>1<\/jats:sub> receptor agonist R\u2010PIA (100\u2003n<jats:sc>M<\/jats:sc>) inhibited the release of [<jats:sup>3<\/jats:sup>H]\u2010acetylcholine (S2\/S1 ratio 0.70\u00b10.03), an effect blocked by DPCPX (S2\/S1 ratio 1.06\u00b10.07).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is concluded that both A<jats:sub>1<\/jats:sub> and A<jats:sub>2A<\/jats:sub> receptors are expressed on striatal cholinergic neurons where they are functionally active.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 886\u2013890; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703366\">10.1038\/sj.bjp.0703366<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703366","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:14:42Z","timestamp":1106946882000},"page":"886-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Adenosine receptor expression and function in rat striatal cholinergic interneurons"],"prefix":"10.1111","volume":"130","author":[{"given":"Zoe","family":"Preston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Widdowson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom C","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair K","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00187-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490230304"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb08817.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15561.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.19.4426"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90173-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01160-7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90104-I"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67010374.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018850"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00004917"},{"key":"e_1_2_6_13_1","first-page":"801","article-title":"Effects of adenosine A1 & A2 receptor activation on electrically evoked dopamine & acetylcholine release from rat striatal slices","volume":"267","author":"JIN S.Y.","year":"1993","journal-title":"J. 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