{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:56:11Z","timestamp":1781117771130,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Male DOCA\u2010salt rats exhibit vasoconstriction upon ET<jats:sub>B<\/jats:sub> activation. Because hypertension is less severe in female than male DOCA rats, we hypothesized that female DOCA rats would display attenuated ET<jats:sub>B<\/jats:sub> vasoconstrictor responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Uninephrectomized Wistar rats received DOCA and drinking water containing NaCl\/KCl. Control rats received vehicle and tap water. Systolic blood pressure was higher in male <jats:italic>vs<\/jats:italic> female DOCA rats. Responses to endothelin\u20101 (ET\u20101), IRL\u20101620, an ET<jats:sub>B<\/jats:sub> agonist, and acetylcholine were evaluated in isolated aortas and <jats:italic>in vivo<\/jats:italic> in the mesenteric microcirculation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Endothelium\u2010denuded aortas from male, but not female, DOCA rats displayed increased sensitivity to ET\u20101. IRL\u20101620 contracted aortas from male DOCA rats, but not control or female DOCA aortas. Noradrenaline\u2010constricted and endothelium\u2010intact aortas from male, but not female, DOCA rats displayed increased relaxation to IRL\u20101620 compared to control aortas.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p> <jats:italic>In vivo<\/jats:italic>, increased vasoconstriction to ET\u20101 was observed in male and female DOCA rats. IRL\u20101620 induced vasodilation in control rats, but vasoconstriction in male DOCA rats. There were minimal changes in diameter in vessels from female DOCA rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The initial fall in blood pressure induced by ET\u20101 and IRL\u20101620 was attenuated in male DOCA rats. Bosentan, a mixed ET<jats:sub>A<\/jats:sub>\/ET<jats:sub>B<\/jats:sub> receptor antagonist, lowered blood pressure in male and female DOCA rats, but a greater and marked decrease occurred in the male DOCA group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The gender\u2010related differences in ET\u20101\/ET<jats:sub>B<\/jats:sub>\u2010mediated effects both in the vasculature and blood pressure suggest that sex\u2010related functional up\u2010regulation of ET<jats:sub>B<\/jats:sub> receptors may play a role in the more severe hypertension in male DOCA hypertensive rats.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 1092\u20131098; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703389\">10.1038\/sj.bjp.0703389<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703389","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:15:45Z","timestamp":1106946945000},"page":"1092-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Deoxycorticosterone acetate\u2010salt hypertensive rats display gender\u2010related differences in ET<sub>B<\/sub> receptor\u2010mediated vascular responses"],"prefix":"10.1111","volume":"130","author":[{"given":"Rita C A Tostes","family":"Passaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Lucia","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleica B","family":"Fortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Scivoletto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena","family":"Catelli de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"H65","article-title":"Chronic increases in blood flow upregulate endothelin\u2010B receptors in arterial smooth muscle","volume":"270","author":"BARBER D.A.","year":"1996","journal-title":"Am. 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