{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:27:51Z","timestamp":1790123271732,"version":"4.0.1"},"reference-count":80,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Phencyclidine (PCP) is widely used as an animal model of schizophrenia. The aim of this study was to better understand the role of nitric oxide (NO) in the mechanism of action of PCP and to determine whether positive NO modulators may provide a new approach to the treatment of schizophrenia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effects of the NO donor, sodium nitroprusside (SNP), were studied in PCP\u2010treated rats. Following drug administration, behavioural changes and the expression of c\u2010<jats:italic>fos<\/jats:italic>, a metabolic marker of functional pathways in the brain, were simultaneously monitored.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Acute PCP (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) treatment induced a complex behavioural syndrome, consisting of hyperlocomotion, stereotyped behaviours and ataxia. Treatment with SNP (2\u20136\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.) by itself produced no effect on any behaviour studied but completely abolished PCP\u2010induced behaviour in a dose\u2010 and time\u2010dependent manner.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>PCP had differential regional effects on c\u2010<jats:italic>fos<\/jats:italic> expression in rat brain, suggesting regionally different patterns of neuronal activity. The most prominent immunostaining was observed in the cortical regions. Pre\u2010treatment with SNP blocked PCP\u2010induced c\u2010<jats:italic>fos<\/jats:italic> expression at doses similar to those that suppress PCP\u2010induced behavioural effects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results implicate the NO system in the mechanism of action of PCP. The fact that SNP abolished effects of PCP suggests that drugs targeting the glutamate\u2010NO system may represent a novel approach to the treatment of PCP\u2010induced psychosis and schizophrenia.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 1005\u20131012; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703406\">10.1038\/sj.bjp.0703406<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703406","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:15:45Z","timestamp":1106946945000},"page":"1005-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Blockade of phencyclidine\u2010induced effects by a nitric oxide donor"],"prefix":"10.1111","volume":"130","author":[{"given":"M","family":"Bujas\u2010Bobanovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1586"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1523\/JNEUROSCI.15-03-02272.1995","article-title":"Progesterone enhances an estradiol\u2010induced increase in fos immunoreactivity in localized regions of female rat forebrain","volume":"15","author":"AUGER A.P.","year":"1995","journal-title":"J. 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