{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:00:00Z","timestamp":1778943600584,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>In <jats:italic>Suncus murinus<\/jats:italic> the ultrapotent capsaicin analogue resiniferatoxin (RTX) induced an emetic response in the dose range 1\u20131000\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c. The latency was inversely related to dose and ranged from 41.2\u00b14.4\u2003min. (1\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) to 2.7\u00b10.6\u2003min. (1000\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The emetic response to RTX (10 or 100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) was blocked or markedly reduced by pre\u2010treatment with RTX (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.), 8\u2010OH\u2010DPAT (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.), morphine (2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.), neonatal capsaicin (100\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) and the NK<jats:sub>1<\/jats:sub> receptor antagonist CP\u201099,994 (10\u201320\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) but not by the 5\u2010HT<jats:sub>3<\/jats:sub> receptor antagonist tropisetron (200\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RTX (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) induced c\u2010<jats:italic>fos<\/jats:italic>\u2010like immunoreactivity in the area postrema and parts of the nucleus tractus solitarius. This pattern is consistent with the proposal that the emetic effect is mediated <jats:italic>via<\/jats:italic> one or both of these structures and an involvement of substance P is discussed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RTX (10\u2003and 100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) had broad\u2010spectrum antiemetic effects in Suncus as indicated by its ability to block or markedly reduce the emetic response to motion (1\u2003Hz, 4\u2003cm lateral, 10\u2003min.), cisplatin (20\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.p.), intragastric copper sulphate (40\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, p.o.), nicotine (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) and RTX (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) itself.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is proposed that the site of the anti\u2010emetic effect is in the nucleus tractus solitarius and mechanisms involving the modulation of substance P release are discussed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The general utility of <jats:italic>Suncus<\/jats:italic> for investigations of vanilloid receptors is reviewed in the light of the exquisite sensitivity of the emetic reflex in this species to resiniferatoxin.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 1247\u20131254; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703428\">10.1038\/sj.bjp.0703428<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703428","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:16:10Z","timestamp":1106946970000},"page":"1247-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["The emetic and anti\u2010emetic effects of the capsaicin analogue resiniferatoxin in <i>Suncus murinus<\/i>, the house musk shrew"],"prefix":"10.1111","volume":"130","author":[{"given":"P L R","family":"Andrews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kakaimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"191","article-title":"Classification and biology of Japanese Insectivore (Mammalia). 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