{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:14:46Z","timestamp":1767860086177,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3103,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The possible existence of a \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptor (\u03b2<jats:sub>3<\/jats:sub>\u2010AR) in human near\u2010term myometrium was investigated by <jats:italic>in vitro<\/jats:italic> functional and biochemical studies and analysis of mRNA expression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SR\u200359119A and SR\u200359104A and CGP\u200312177 (two selective agonists and a partial agonist, respectively, of the \u03b2<jats:sub>3<\/jats:sub>\u2010AR), salbutamol and terbutaline (\u03b2<jats:sub>2<\/jats:sub>\u2010AR agonists) each produced a concentration\u2010dependent relaxation of the myometrial spontaneous contractions. There were no differences in pD<jats:sub>2<\/jats:sub> values for the relaxing potencies of terbutaline, salbutamol, CGP\u200312177 and SR\u200359119A. The rank order for their relaxing efficacies was SR\u200359119A&gt;SR\u200359104A&gt;terbutaline\u223csalbutamol\u223cCGP\u200312177 (E<jats:sub>max<\/jats:sub>=52\u00b17%, 42\u00b112% and \u223c 30% respectively).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Propranolol, a \u03b2<jats:sub>1<\/jats:sub>\u2010 and \u03b2<jats:sub>2<\/jats:sub>\u2010AR antagonist, and ICI\u2003118551, a \u03b2<jats:sub>2<\/jats:sub>\u2010AR antagonist (both at 0.1\u2003\u03bc<jats:sc>M<\/jats:sc>), did not affect the SR\u200359119A\u2010induced relaxation whereas SR\u200359230A, a selective \u03b2<jats:sub>3<\/jats:sub>\u2010AR antagonist (1\u2003\u03bc<jats:sc>M<\/jats:sc>), significantly reduced the maximal relaxing effect of SR\u200359119A.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SR\u200359119A and salbutamol induced a significant increase in cyclic AMP levels that was antagonized by SR\u200359230A but not by propranolol for SR\u200359119A, and by propranolol but not by SR\u200359230A for salbutamol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The \u03b2<jats:sub>3<\/jats:sub>\u2010AR mRNA was positively expressed in myometrium preparations in a reverse transcription polymerase chain assay.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results presented provide the first evidence for the existence of the \u03b2<jats:sub>3<\/jats:sub>\u2010AR subtype in human near\u2010term myometrium and suggest that the effects of SR\u200359119A might be mediated through an increase in cyclic AMP level.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>130<\/jats:bold>, 1960\u20131966; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703491\">10.1038\/sj.bjp.0703491<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703491","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:46:59Z","timestamp":1106945219000},"page":"1960-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Functional, biochemical and molecular biological evidence for a possible \u03b2<sub>3<\/sub>\u2010adrenoceptor in human near\u2010term myometrium"],"prefix":"10.1111","volume":"130","author":[{"given":"M","family":"Bardou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Loustalot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Cortijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Naline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Croci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Chalon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Sagot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Manara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Advenier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000299848"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/309163a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900092"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00419-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90310-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90366-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(95)90098-5"},{"key":"e_1_2_7_9_1","first-page":"1444","article-title":"Beta\u20103 adrenoceptor\u2010mediated increase in cutaneous blood flow in the dog","volume":"268","author":"BERLAN M.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11698.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90500-6"},{"key":"e_1_2_7_12_1","first-page":"649","article-title":"Potent and selective human beta(3)\u2010adrenergic receptor antagonists","volume":"290","author":"CANDELORE M.R.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15294.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb02086.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9667"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(94)90118-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"215S","DOI":"10.1093\/ajcn\/55.1.215s","article-title":"The human beta 3\u2010adrenergic receptor: relationship with atypical receptors","volume":"55","author":"EMORINE L.J.","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2570461"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod60.2.322"},{"key":"e_1_2_7_21_1","first-page":"753","article-title":"Coexisting beta 1\u2010 and atypical beta\u2010adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells","volume":"42","author":"ESBENSHADE T.A.","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2191"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118823"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390506"},{"key":"e_1_2_7_25_1","first-page":"264","article-title":"Characterization of the human beta 3\u2010adrenergic receptor gene","volume":"44","author":"GRANNEMAN J.G.","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)02701-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90065-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15648.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00004999"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/mol.53.4.670","article-title":"(\u2212)\u2010CGP\u200312177 causes cardiostimulation and binds to cardiac putative beta 4\u2010adrenoceptors in both wild\u2010type and beta 3\u2010adrenoceptor knockout mice","volume":"53","author":"KAUMANN A.J.","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12457.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116191"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/214597a0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(67)90031-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90142-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702709"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13902.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.1999.00121.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00104-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701516"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90247-6"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15209.x"},{"key":"e_1_2_7_43_1","first-page":"1041","article-title":"Characterization of beta\u20101 and beta\u20102 adrenoceptors in guinea pig atrium: functional and receptor binding studies","volume":"241","author":"MOLENAAR P.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13311.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"13148","DOI":"10.1016\/S0021-9258(17)36811-4","article-title":"Cell\u2010specific down\u2010regulation of the beta 3\u2010adrenergic receptor","volume":"269","author":"NANTEL F.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702403"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb17206.x"},{"key":"e_1_2_7_48_1","first-page":"466","article-title":"Peripheral vascular effects of beta\u20103 adrenergic receptor stimulation in conscious dogs","volume":"268","author":"SHEN Y.T.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1988.tb01130.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560020802"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02173535"},{"key":"e_1_2_7_52_1","first-page":"376","article-title":"Role of cyclic nucleotide phosphodiesterase isozymes in intact canine trachealis","volume":"39","author":"TORPHY T.J.","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702797"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90032-4"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703491","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0703491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T16:11:59Z","timestamp":1698595919000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0703491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1038\/sj.bjp.0703491"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0703491","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}