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Field excitatory postsynaptic potentials (fEPSP) were recorded from CA1.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DHPG (100\u2003\u03bc<jats:sc>M<\/jats:sc>), a group I agonist, produced a slowly developing enhancement of fEPSP slope in slices from adults. In slices from neonates, DHPG (75\u2003\u03bc<jats:sc>M<\/jats:sc>) depressed fEPSP slope.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DCG\u2010IV (500\u2003n<jats:sc>M<\/jats:sc>), a group II agonist, did not affect the fEPSP recorded from slices from adults whereas perfusion in neonate slices produced a sustained depression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The group III agonist <jats:italic>L<\/jats:italic>\u2010AP4 (50\u2003\u03bc<jats:sc>M<\/jats:sc>) was ineffective in adult slices but depressed fEPSP slope in slices prepared from neonates.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DHPG\u2010induced depression of fEPSP slope was inhibited by 4\u2010CPG (400\u2003\u03bc<jats:sc>M<\/jats:sc>), a group I antagonist, but was unaffected by MCCG (500\u2003\u03bc<jats:sc>M<\/jats:sc>) and MAP4 (500\u2003\u03bc<jats:sc>M<\/jats:sc>), group II and III receptor antagonists respectively. MCCG but not MAP4 antagonized the effects of DCG\u2010IV with 4\u2010CPG producing variable effects. The effect of <jats:italic>L<\/jats:italic>\u2010AP4 was unaffected by MCCG, blocked by MAP4, and enhanced by 4\u2010CPG.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results show that the effects of the agonists for all groups of mGlu receptors are developmentally regulated. Furthermore, MCCG and MAP4 behave as effective and selective antagonists for group II and group III mGlu receptors respectively, whereas the usefulness of 4\u2010CPG as a group I antagonist may be limited.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>131<\/jats:bold>, 453\u2013464; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703610\">10.1038\/sj.bjp.0703610<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703610","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:52:44Z","timestamp":1106945564000},"page":"453-464","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors"],"prefix":"10.1111","volume":"131","author":[{"given":"F M","family":"Ross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S N","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"665","article-title":"A data acquisition program for on\u2010line analysis of long\u2010term potentiation and long\u2010term depression","volume":"23","author":"ANDERSON W.","year":"1997","journal-title":"Neurosci. 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