{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:16:28Z","timestamp":1698642988269},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We previously reported activation of an inhibitory adrenergic and a non\u2010adrenergic non\u2010cholinergic (NANC) pathway during abdominal surgery relaxing the rat gastric fundus. In the present study, we investigated the possible role of nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) in the NANC part of the surgery\u2010induced fundic relaxation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effect of the NO biosynthesis inhibitor N<jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine (<jats:sc>L<\/jats:sc>\u2010NOARG), the non\u2010selective VIP receptor antagonist [<jats:sc>D<\/jats:sc>\u2010p\u2010Cl\u2010Phe<jats:sup>6<\/jats:sup>,Leu<jats:sup>17<\/jats:sup>]\u2010VIP and the selective VIP<jats:sub>1<\/jats:sub> receptor antagonist [Acetyl\u2010His<jats:sup>1<\/jats:sup>,<jats:sc>D<\/jats:sc>\u2010Phe<jats:sup>2<\/jats:sup>,Lys<jats:sup>15<\/jats:sup>,Arg<jats:sup>16<\/jats:sup>,Leu<jats:sup>17<\/jats:sup>]\u2010VIP was investigated on the non\u2010adrenergic fundic relaxation induced by manipulation of the small intestine followed by resection of the caecum.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Guanethidine partly reduced the manipulation\u2010induced fundic relaxation. Addition of <jats:sc>L<\/jats:sc>\u2010NOARG reduced this non\u2010adrenergic component, whereas the non\u2010selective VIP receptor antagonist had no significant effect. Combination of <jats:sc>L<\/jats:sc>\u2010NOARG and the non\u2010selective VIP antagonist however further reduced the relaxation to manipulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The selective VIP<jats:sub>1<\/jats:sub> receptor antagonist reduced the mean and maximal relaxation induced by abdominal surgery in the presence of guanethidine. When combined with <jats:sc>L<\/jats:sc>\u2010NOARG, the relaxation of the gastric fundus was almost completely abolished. The VIP<jats:sub>1<\/jats:sub> receptor antagonist alone had no significant effect on the mean and maximal relaxation, but enhanced recovery of fundic tone.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, as VIP<jats:sub>1<\/jats:sub> receptors are not present in the rat gastric fundus, these results suggest that the NANC inhibitory pathway activated during abdominal surgery involves VIP<jats:sub>1<\/jats:sub> receptors, most likely in the afferent limb. The inhibitory neurotransmitters released at the level of the gastric fundus smooth muscle are NO and a substance different from VIP.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>131<\/jats:bold>, 705\u2013710; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703625\">10.1038\/sj.bjp.0703625<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703625","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:58:37Z","timestamp":1106945917000},"page":"705-710","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evidence for VIP<sub>1<\/sub>\/PACAP receptors in the afferent pathway mediating surgery\u2010induced fundic relaxation in the rat"],"prefix":"10.1111","volume":"131","author":[{"given":"G E","family":"Boeckxstaens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Heisterkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Robberecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"De Jonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M J G J","family":"Van Den Wijngaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G N J","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J E","family":"Blommaart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527909179853"},{"key":"e_1_2_7_3_1","first-page":"R888","article-title":"Neuronal pathways involved in abdominal surgery\u2010induced gastric ileus in rats","volume":"270","author":"BARQUIST E.","year":"1996","journal-title":"Am. 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