{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T04:31:54Z","timestamp":1716957114309},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":3042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We have previously reported that the renal kallikrein\u2010kinin system suppressed the development of deoxycorticosterone acetate (DOCA)\u2010salt hypertension. Kinins were degraded in the kidney mainly by carboxypeptidase Y (CPY)\u2010like kininase. Blockade of renal kinin degradation may reduce hypertension in the developmental stage.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We constructed an antisense oligonucleotide against rat CPY homologue (5\u2032\u2010<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"CAT-CTC-TGC-TTC-CTT-GTG-TC\">CAT\u2010CTC\u2010TGC\u2010TTC\u2010CTT\u2010GTG\u2010TC<\/jats:ext-link>\u20103\u2032, AS) and its randomized control oligonucleotide (5\u2032\u2010<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"TCC-TTC-CTG-CTT-GAG-TTC-CT\">TCC\u2010TTC\u2010CTG\u2010CTT\u2010GAG\u2010TTC\u2010CT<\/jats:ext-link>\u20103\u2032, RC), and prepared an HVJ\u2010liposome complex that prolongs and increases the effectiveness of the antisense oligonucleotide. Antisense oligonucleotide was transfected (25\u2003nmole rat<jats:sup>\u22121<\/jats:sup>, in terms of nucleotide) into the kidney from the renal artery.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blood pressure was measured through a catheter inserted into the abdominal aorta. Mean blood pressure (MBP) in DOCA\u2010salt treated (for 2 weeks) Sprague Dawley strain rats was 130\u00b13\u2003mmHg (<jats:italic>n<\/jats:italic>=11), and was reduced significantly (<jats:italic>P<\/jats:italic>&lt;0.05) more by AS transfection (122\u00b14\u2003mmHg, <jats:italic>n<\/jats:italic>=6) than by RC treatment (137\u00b16\u2003mmHg, <jats:italic>n<\/jats:italic>=5) 4 days after the transfection.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This reduction in MBP was accompanied by increased urinary sodium excretion (AS, 8.4\u00b11.5\u2003mmole day<jats:sup>\u22121<\/jats:sup>; RC, 4.6\u00b10.5\u2003mmole day<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>&lt;0.05) and a reduction in urinary CPY\u2010like kininase activity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ebelactone B (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, twice a day, p.o.), an inhibitor for urinary CPY\u2010like kininase, also reduced MBP and induced natriuresis to the same degree as AS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Lisinopril, an inhibitor for angiotensin converting enzyme (ACE) failed to reduce the elevated MBP.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that CPY\u2010like kininase may have more contribution than ACE to degrade kinin in the kidney, and that knockdown of CPY\u2010like kininase in the kidney may partly prevent rat DOCA\u2010salt hypertension.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>131<\/jats:bold>, 820\u2013826; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703634\">10.1038\/sj.bjp.0703634<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703634","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:58:37Z","timestamp":1106945917000},"page":"820-826","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>In vivo<\/i> transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate\u2010salt hypertension in rats"],"prefix":"10.1111","volume":"131","author":[{"given":"Izumi","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Majima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoe","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruya","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitsuo","family":"Higaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ogiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7595"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(92)90100-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.1.483"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)90999-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1016\/S0021-9258(19)39616-4","article-title":"Mouse protective protein; cDNA cloning, sequence comparison and expression","volume":"265","author":"GALJART N.J.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(90)90031-V"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702340"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00159a059"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"11265","DOI":"10.1016\/S0021-9258(19)38586-2","article-title":"A peptidase in human platelets that deamidates tachykinins","volume":"265","author":"JACKMAN H.L.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2911748"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63828-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60127-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1299224"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2220\/biomedres.14.191","article-title":"Major kininases in rat urine are neutral endopeptidase and carboxypeptidase Y\u2010like exopeptidase","volume":"14","author":"KURIBAYASHI Y.","year":"1993","journal-title":"Biomed. Res."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.69.149"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00320-K"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.65.79"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.1.111"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02252938"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.5.705"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(88)90447-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117123"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8474"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116496"},{"key":"e_1_2_7_26_1","first-page":"181","article-title":"Degradation of bradykinin in human urine by carboxypeptidase Y\u2010like exopeptidase and neutral endopeptidase and their inhibition by ebelactone B and phosphoramidon","volume":"17","author":"SAITO M.","year":"1995","journal-title":"Int. J. Tiss. Reac."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00033-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1016\/S0021-9258(19)50598-1","article-title":"Acylpeptide hydrolase; inhibitors and some active site residues of the human enzyme","volume":"267","author":"SCALONI A.W.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_29_1","first-page":"1792","article-title":"Antisense oligonucleotides as a therapeutic agents","volume":"258","author":"STEIN C.A.","year":"1993","journal-title":"Science"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00139a021"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.5.898"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80784-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.1.131"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199512010-00048"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.239"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703634","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0703634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T14:13:04Z","timestamp":1698588784000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0703634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1038\/sj.bjp.0703634"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0703634","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}