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In contrast WIN55,212\u20102 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10\u201313 days old) rats. This effect was stereoselective and blocked by the CB<jats:sub>1<\/jats:sub> receptor antagonist AM281 (500\u2003n<jats:sc>M<\/jats:sc>). The results indicate that activation of CB<jats:sub>1<\/jats:sub> receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB<jats:sub>1<\/jats:sub> receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the literature.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>131<\/jats:bold>, 663\u2013665; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703642\">10.1038\/sj.bjp.0703642<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703642","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T20:58:37Z","timestamp":1106945917000},"page":"663-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated"],"prefix":"10.1111","volume":"131","author":[{"given":"Abdulmonem","family":"Al\u2010Hayani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen N","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"585","article-title":"Cannabinoid effects on paired pulse depression in the rat hippocampal slice","volume":"25","author":"AL\u2010HAYANI A.","year":"1999","journal-title":"Soc. 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