{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:27:11Z","timestamp":1781191631253,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2981,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Exposure to midrange ultraviolet radiation (UVB) is known to produce skin inflammation similar to sunburn. The aim of this study was to characterize the hyperalgesia and cytokine upregulation induced by UVB and their modulation by antiinflammatory cytokines.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Acute exposure of the dorsal skin of mice to UVB (200, 250 and 300\u2003mJ\u2003cm<jats:sup>2<\/jats:sup>) resulted in a dose\u2010dependent decrease in the latencies of the hot plate and tail flick tests, without evident signs of skin lesions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The observed hyperalgesia displayed a biphasic temporal evolution with an acute phase (3\u20136\u2003h) and a late (48\u201396\u2003h) phase.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Exposure to UVB (300\u2003mJ\u2003cm<jats:sup>2<\/jats:sup>) elicited significant upregulation of interleukin (IL)\u20101\u03b2, tumour necrosis factor (TNF)\u2010\u03b1 and nerve growth factor (NGF), determined by ELISA in the exposed skin. This upregulation was more important during the acute phase of hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Daily treatment of mice, with i.p. injections of either IL\u201010 or IL\u201013 (1.5, 7.5 and 15\u2003ng in 100\u2003\u03bcl saline) produced a dose\u2010dependent attenuation of the UVB\u2010induced hyperalgesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Treatment with the highest doses of either IL\u201010 or IL\u201013, produced significant attenuation of the levels of the cytokines and NGF by UVB, with relatively more pronounced effects by IL\u201013.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Acute exposure to moderate amounts of UVB results in a systemic hyperalgesia related to the upregulation of cytokine and NGF levels, since both were prevented by treatment with antiinflammatory cytokines.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2000) <jats:bold>131<\/jats:bold>, 1317\u20131324; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703699\">10.1038\/sj.bjp.0703699<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703699","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:00:44Z","timestamp":1106946044000},"page":"1317-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Modulation of ultraviolet\u2010induced hyperalgesia and cytokine upregulation by interleukins 10 and 13"],"prefix":"10.1111","volume":"131","author":[{"given":"Nayef E","family":"Saad\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam W","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A","family":"Massaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bared","family":"Safieh\u2010Garabedian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhayl J","family":"Jabbur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim A","family":"Kanaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00024-M"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4049\/jimmunol.143.6.1737","article-title":"Regulation of murine lymphokine production in vivo. 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