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This study examined the up\u2010regulation of haemodynamic and pro\u2010inflammatory responses to the B<jats:sub>1<\/jats:sub> agonist des\u2010Arg<jats:sup>10<\/jats:sup>\u2010kallidin (dKD) in a non\u2010human primate model.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Green monkeys (<jats:italic>Cercopithecus aethiops St Kitts<\/jats:italic>) received lipopolysaccharide (LPS; 90\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) or saline intravenously. After 4\u2003h, anaesthetized monkeys were canulated <jats:italic>via<\/jats:italic> the carotid artery to monitor blood pressure changes following intra\u2010arterial injections of dKD or the B<jats:sub>2<\/jats:sub> agonist bradykinin (BK). Oedema induced by subcutaneous kinin administration was evaluated as the increase in ventral skin folds in anaesthetized monkeys injected with captopril at 4\u2003h to 56 days post\u2010LPS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LPS increased rectal temperature but did not affect blood pressure after 4\u2003h. dKD reduced blood pressure (E<jats:sub>max<\/jats:sub>: 27\u00b14\u2003mmHg; EC<jats:sub>50<\/jats:sub>: 130\u2003pmol\u2003kg<jats:sup>\u22121<\/jats:sup>) and increased heart rate (E<jats:sub>max<\/jats:sub>: 33 b.p.m.) only after LPS. In contrast, the dose\u2010dependent fall in blood pressure with BK was comparable in all groups. The selective B<jats:sub>1<\/jats:sub> antagonist [Leu<jats:sup>9<\/jats:sup>]dKD (75\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup>, intravenously) abolished responses to dKD but not BK.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>dKD injection induced oedema dose\u2010dependently (2.4\u00b10.1\u2003mm at 150\u2003nmol) only following LPS (at 4\u2003h to 12 days but not 56 days). In contrast, BK\u2010induced oedema was present and stable in all monkeys. Co\u2010administration of [Leu<jats:sup>9<\/jats:sup>]dKD (150\u2003nmol) significantly reduced oedema induced by dKD (50\u2003nmol).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest LPS up\u2010regulation of B<jats:sub>1<\/jats:sub> receptor effects in green monkeys. This non\u2010human primate model may be suitable for testing new, selective B<jats:sub>1<\/jats:sub> antagonists with therapeutic potential as anti\u2010inflammatory agents.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 327\u2013335; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703748\">10.1038\/sj.bjp.0703748<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703748","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:06:00Z","timestamp":1106946360000},"page":"327-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Endotoxin sensitization to kinin B<sub>1<\/sub> receptor agonist in a non\u2010human primate model: haemodynamic and pro\u2010inflammatory effects"],"prefix":"10.1111","volume":"132","author":[{"given":"Denis","family":"DeBlois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Horlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01321-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00003-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90819-2"},{"key":"e_1_2_7_5_1","first-page":"6","article-title":"Cardiovascular effects of Sar\u2010[D\u2010Phe8]des\u2010Arg9\u2010bradykinin, a metabolically protected agonist of B1 receptor for kinins, in the anesthetized rabbit pretreated with a sublethal dose of bacterial lipopolysaccharide","volume":"280","author":"AUDET R.","year":"1997","journal-title":"J. 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