{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:35:38Z","timestamp":1772728538920,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2950,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effect of chlorpromazine on the store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry activated <jats:italic>via<\/jats:italic> the phospholipase C signalling pathway was investigated in PC12 cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Chlorpromazine inhibited the sustained increase after the initial peak in the intracellular Ca<jats:sup>2+<\/jats:sup> concentration produced by bradykinin while having no effect on the initial transient response. The inhibition was lowered by the removal of extracellular free Ca<jats:sup>2+<\/jats:sup>. However, chlorpromazine did not inhibit bradykinin\u2010induced inositol 1,4,5\u2010trisphosphate production.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Chlorpromazine inhibited the bradykinin\u2010induced noradrenaline secretion in a concentration\u2010dependent manner (IC<jats:sub>50<\/jats:sub>: 24\u00b15\u2003\u03bc<jats:sc>M<\/jats:sc>, <jats:italic>n<\/jats:italic>=3).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>To test for a direct effect of chlorpromazine on store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry, thapsigargin, an inhibitor of microsomal Ca<jats:sup>2+<\/jats:sup>\u2010ATPase, was used to induce store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry in PC12 cells. Chlorpromazine reduced the thapsigargin\u2010induced sustained Ca<jats:sup>2+<\/jats:sup> level (IC<jats:sub>50<\/jats:sub>: 24\u00b12\u2003\u03bc<jats:sc>M<\/jats:sc>, <jats:italic>n<\/jats:italic>=3), and the inhibition also occluded the inhibitory action of 1\u2010[\u2010[3\u2010(4\u2010methoxyphenyl) propoxy]\u20104\u2010methoxyphenyl]\u20101H\u2010imidazole hydrochloride (SK&amp;F96365).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that chlorpromazine negatively modulates the store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry activated subsequent to PLC activation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 411\u2013418; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703840\">10.1038\/sj.bjp.0703840<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703840","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:09:20Z","timestamp":1106946560000},"page":"411-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Chlorpromazine inhibits store\u2010operated calcium entry and subsequent noradrenaline secretion in PC12 cells"],"prefix":"10.1111","volume":"132","author":[{"given":"Se\u2010Young","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong\u2010Tai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(97)00094-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90918-B"},{"key":"e_1_2_7_4_1","first-page":"107","article-title":"Capsaicin inhibits phospholipase C\u2010mediated Ca2+ increase by blocking thapsigargin\u2010sensitive store\u2010operated Ca2+ entry in PC12 cells","volume":"291","author":"CHOI S.Y.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702749"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90036-D"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-03711.1999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26471"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83641-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01487-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26127"},{"key":"e_1_2_7_12_1","first-page":"H1601","article-title":"Calmodulin antagonists depress calcium and potassium currents in ventricular and vascular myocytes","volume":"253","author":"KLOCKNER U.","year":"1987","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8251"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00181-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1016\/S0021-9258(18)82154-8","article-title":"Inhibition of bradykinin\u2010 and thapsigargin\u2010induced Ca2+ entry by tyrosine kinase inhibitors","volume":"268","author":"LEE K.M.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00423-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(97)90066-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2710515"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1546"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41728-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1523\/JNEUROSCI.19-07-02474.1999","article-title":"Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptors","volume":"19","author":"MOZRYZMAS J.W.","year":"1999","journal-title":"J. Neurosci."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90569-C"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb17214.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.10.4412"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp017906"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68052177.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90085-R"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12346-6"},{"key":"e_1_2_7_29_1","first-page":"509","article-title":"Inhibition of calmodulin by phenothiazines and related drugs: structure\u2010activity relationships","volume":"222","author":"PROZIALECK W.C.","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199901)21:1<38::AID-BIES5>3.0.CO;2-S"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003147200"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80421-3"},{"key":"e_1_2_7_33_1","first-page":"229","article-title":"Brain dopamine receptors","volume":"32","author":"SEEMAN P.","year":"1980","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00167-7"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4143.1243"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00660-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90399-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64031071.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13931.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702661"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.1.501"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703840","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0703840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0703840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T19:11:30Z","timestamp":1697569890000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0703840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1038\/sj.bjp.0703840"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0703840","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}