{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:29:29Z","timestamp":1785716969873,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>This study has investigated the effects adenosine 5\u2032\u2010triphosphate (ATP), analogues of ATP, uridine 5\u2032\u2010triphosphate (UTP) and adenosine on prostaglandin output from the guinea\u2010pig uterus superfused <jats:italic>in vitro<\/jats:italic>, and from guinea\u2010pig endometrium and myometrium cultured for 24\u2003h.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>ATP, 2\u2010methylthio ATP and adenosine increased the outputs of prostaglandin F<jats:sub>2\u03b1<\/jats:sub> (PGF<jats:sub>2\u03b1<\/jats:sub>) and 6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> (reflecting PGI<jats:sub>2<\/jats:sub> production), and UTP increased the output of PGF<jats:sub>2\u03b1<\/jats:sub> from the superfused guinea\u2010pig uterus. These findings support the hypothesis that the contractile effects of ATP, 2\u2010methylthio ATP, UTP and adenosine are mediated by prostaglandins.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Suramin (a P2 receptor antagonist) and 8\u2010sulphophenyltheophylline (an A receptor antagonist) blocked the stimulatory actions of ATP and adenosine, respectively, on PGF<jats:sub>2\u03b1<\/jats:sub> output, suggesting that ATP acts on P2 receptors (probably of the P2Y type) and adenosine acts on A receptors in the guinea\u2010pig uterus to increase PGF<jats:sub>2\u03b1<\/jats:sub> production.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>ATP, 2\u2010methylthio ATP, \u03b1,\u03b2\u2010methylene ATP, \u03b2,\u03b3\u2010methylene ATP, UTP and adenosine increased the output of PGF<jats:sub>2\u03b1<\/jats:sub> from guinea\u2010pig endometrium and myometrium after 24\u2003h of culture, with a greater stimulatory effect being exerted on the endometrium than on the myometrium. Little or no stimulatory effect was seen after 2 and 8\u2003h of culture. In addition the effects of ATP, ATP analogues, UTP and adenosine on the outputs of PGE<jats:sub>2<\/jats:sub> and 6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> from cultured endometrium and myometrium were more variable, with both stimulation and inhibition being observed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The stimulatory effects of ATP and adenosine on PGF<jats:sub>2\u03b1<\/jats:sub> output from the endometrium and myometrium were associated with an increase in the prostaglandin synthesizing capacity of both tissues, due probably to an increase in the amount of prostaglandin H synthase present.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 709\u2013721; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703848\">10.1038\/sj.bjp.0703848<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703848","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:09:45Z","timestamp":1106946585000},"page":"709-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The effects of P2Y receptor agonists and adenosine on prostaglandin production by the guinea\u2010pig uterus"],"prefix":"10.1111","volume":"132","author":[{"given":"Heather","family":"Aitken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N L","family":"Poyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1033","article-title":"Adenosine\u2010stimulated contraction in nonpregnant guinea\u2010pig myometrium does not involve cyclooxygenase","volume":"264","author":"BRADLEY M.E.","year":"1993","journal-title":"J. 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