{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:09:27Z","timestamp":1760216967782},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Chronic inhibition of nitric oxide synthase (NOS) provokes a hypertensive state which has been shown to be angiotensin II (Ang\u2010II) dependent. In addition to raising blood pressure, NOS inhibition also causes leukocyte adhesion. The present study was designed to define the role of Ang\u2010II in hypertension and in the leukocyte\u2010endothelial cell interactions induced by acute NOS or cyclo\u2010oxygenase (COX) inhibition using intravital microscopy within the rat mesenteric microcirculation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>While pretreatment with an Ang\u2010II AT<jats:sub>1<\/jats:sub> receptor antagonist (losartan) reversed the prompt increase in mean arterial blood pressure (MABP) caused by indomethacin, it had no effect on the increase evoked by systemic <jats:sc>L<\/jats:sc>\u2010NAME administration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment with losartan inhibited the leukocyte rolling flux, adhesion and emigration which occurs after 60\u2003min NOS inhibition by 83, 80 and 70% respectively, and returned leukocyte rolling velocity to basal levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Losartan significantly reduced the leukocyte\u2010endothelial cell interaction elicited by COX inhibition. In contrast, leukocyte recruitment induced by acute mast cell activation was not inhibited by losartan.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>AT<jats:sub>1<\/jats:sub> receptor blockade also prevented the drop in haemodynamic parameters such as mean red blood cell velocity (V<jats:sub>mean<\/jats:sub>) and shear rate caused by NOS and COX inhibition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study, we have demonstrated a clear role for Ang\u2010II in the leukocyte\u2010endothelial cell interactions and haemodynamic changes which arise in the absence of NO or prostacyclin (PGI<jats:sub>2<\/jats:sub>). This is of interest since leukocyte recruitment, which culminates in the vascular lesions that occur in hypertension, atherosclerosis and myocardial ischemia\u2010reperfusion injury, might be prevented using AT<jats:sub>1<\/jats:sub> Ang\u2010II receptor antagonists.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 677\u2013684; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703867\">10.1038\/sj.bjp.0703867<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703867","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:09:45Z","timestamp":1106946585000},"page":"677-684","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Angiotensin II is involved in nitric oxide synthase and cyclo\u2010oxygenase inhibition\u2010induced leukocyte\u2010endothelialcell interactions <i>in vivo<\/i>"],"prefix":"10.1111","volume":"132","author":[{"given":"Angeles","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Piqueras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Canet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrecia","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kubes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Jesus","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.3.514"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104183241605"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90882-D"},{"key":"e_1_2_7_5_1","first-page":"II3","article-title":"Coronary atherosclerosis. 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