{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:13:20Z","timestamp":1791245600701,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>\n                          The release\u2010inhibiting \u03b1\n                          <jats:sub>2<\/jats:sub>\n                          \u2010adrenoceptors of cerebral serotoninergic axons were studied in mice. Slices of the hippocampus or the occipito\u2010parietal cortex from NMRI mice, from mice lacking the \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010, the \u03b1\n                          <jats:sub>2B<\/jats:sub>\n                          \u2010, the \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010 or both the \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010 and the \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010adrenoceptor, and from mice sharing the genetic background of the receptor\u2010deficient animals (WT) were preincubated with [\n                          <jats:sup>3<\/jats:sup>\n                          H]\u2010serotonin and then superfused and stimulated electrically, in most experiments by trains of 8 pulses at 100\u2003Hz.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          The concentration\u2010response curves of the \u03b1\n                          <jats:sub>2<\/jats:sub>\n                          \u2010adrenoceptor agonist medetomidine were virtually identical in hippocampal slices from NMRI and WT mice, with maximally 70% inhibition and an EC\n                          <jats:sub>50<\/jats:sub>\n                          of about 2\u2003n\n                          <jats:sc>M<\/jats:sc>\n                          . In hippocampal slices from NMRI mice, phentolamine and rauwolscine were equipotent antagonists against medetomidine.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          The effect of medetomidine was greatly reduced, with maximally 20% inhibition, in hippocampal slices from \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010adrenoceptor\u2010deficient mice; was slightly reduced, with maximally 59% inhibition, in hippocampal slices from \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010adrenoceptor\u2010deficient mice; was not changed in hippocampal slices from \u03b1\n                          <jats:sub>2B<\/jats:sub>\n                          \u2010adrenoceptor\u2010deficient mice; and was abolished in hippocampal slices from mice lacking both the \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010 and the \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010adrenoceptor.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Similar results were obtained in: (i) occipito\u2010parietal slices from NMRI and \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010adrenoceptor\u2010deficient mice and (ii) hippocampal slices that were preincubated with [\n                          <jats:sup>3<\/jats:sup>\n                          H]\u2010serotonin in the presence of oxaprotiline to rule out cross\u2010labelling of noradrenergic axons.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          The serotoninergic axons of the mouse brain possess both \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010heteroreceptors, which predominate, and \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010heteroreceptors but lack \u03b1\n                          <jats:sub>2B<\/jats:sub>\n                          \u2010adrenoceptors. The situation resembles the coexistence of \u03b1\n                          <jats:sub>2A\/D<\/jats:sub>\n                          \u2010 and \u03b1\n                          <jats:sub>2C<\/jats:sub>\n                          \u2010autoreceptors but lack of \u03b1\n                          <jats:sub>2B<\/jats:sub>\n                          \u2010autoreceptors at the noradrenergic axons of mice.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>British Journal of Pharmacology<\/jats:italic>\n                    (2001)\n                    <jats:bold>132<\/jats:bold>\n                    , 925\u2013933; doi:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703882\">10.1038\/sj.bjp.0703882<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1038\/sj.bjp.0703882","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T16:10:46Z","timestamp":1106928646000},"page":"925-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["\u03b1\n                    <sub>2<\/sub>\n                    \u2010Adrenoceptors modulating neuronal serotonin release: a study in \u03b1\n                    <sub>2<\/sub>\n                    \u2010adrenoceptor subtype\u2010deficient mice"],"prefix":"10.1111","volume":"132","author":[{"given":"Jens","family":"Scheibner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Ulrike","family":"Trendelenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Starke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.56.1.154"},{"key":"e_1_2_7_3_1","first-page":"121","article-title":"International Union of Pharmacology nomenclature of adrenoceptors","volume":"46","author":"BYLUND D.B.","year":"1994","journal-title":"Pharmacol. 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