{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:02Z","timestamp":1760204042448},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item>\n<jats:p>We showed previously that interaction between NO and iron(II), both released following decomposition of sodium nitroprusside (SNP), accounted for the late SNP\u2010induced dopamine (DA) increase in dialysates from the striatum of freely moving rats.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>In this study, intrastriatal infusion of the NO\u2010donor S\u2010nitroso\u2010N\u2010acetylpenicillamine (SNAP) (0.2\u2003m<jats:sc>M<\/jats:sc> for 180\u2003min) induced a moderate increase in dialysate DA and decreases in ascorbic acid dialysate concentrations; in contrast, SNAP 1\u2003m<jats:sc>M<\/jats:sc> infusion induced a long\u2010lasting decrease in both DA and ascorbic acid dialysate concentrations. 3\u2010Methoxy\u2010tyramine (3\u2010MT), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and uric acid levels were unaffected.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Co\u2010infusion of ferrous sulphate [iron(II), 1\u2003m<jats:sc>M<\/jats:sc> for 40\u2003min] with SNAP either 1 or 0.2\u2003m<jats:sc>M<\/jats:sc> (for 180\u2003min), produced a significant increase in both DA and 3\u2010MT dialysate concentrations, but it did not affect decreases in dialysate ascorbic acid levels. All other dialysate neurochemicals were unaffected.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Co\u2010infusion of ascorbic acid (0.1\u2003m<jats:sc>M<\/jats:sc>) with SNAP (1\u2003m<jats:sc>M<\/jats:sc>) for 180\u2003min did not modify SNAP\u2010induced decreases in dialysate DA levels. In contrast, co\u2010infusion of uric acid (1\u2003m<jats:sc>M<\/jats:sc>) reversed SNAP\u2010induced decreases in dialysate DA; co\u2010infusion of a superoxide dismutase mimetic delayed SNAP\u2010induced DA decreases for a short period, while co\u2010infusion of the antioxidant N\u2010acetylcysteine (NAC, 0.1\u2003m<jats:sc>M<\/jats:sc>) significantly increased dialysate DA.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The results of this study show that SNAP induces concentration\u2010related changes in DA dialysate levels. At higher concentrations, SNAP induces non\u2010enzymatic DA oxidation, which is inhibited by uric acid and NAC; ascorbic acid failed to protect dialysate DA from oxidation, probably owing to its promoting effect on SNAP decomposition; exogenous iron(II) may react with NO generated from SNAP decomposition, with a consequent increase in dialysate DA and 3\u2010MT, therefore mimicking SNP effects on striatal DA release.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 941\u2013949; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703887\">10.1038\/sj.bjp.0703887<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703887","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:10:46Z","timestamp":1106946646000},"page":"941-949","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of S\u2010nitroso\u2010N\u2010acetylpenicillamine effects on dopamine release in the striatum of freely moving rats: role of endogenous ascorbic acid and oxidative stress"],"prefix":"10.1111","volume":"132","author":[{"given":"Pier Andrea","family":"Serra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Rosaria","family":"Delogu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Migheli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Rocchitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egidio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S","family":"Desole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90406-U"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90143-I"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)81094-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90285-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-6989(87)90083-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702120"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.003343"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62020807.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00249-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00009-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.2.675"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.9.916"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1891"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-02-00687.1998"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0730247.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13635"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260173"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701571"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(98)00072-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90316-6"},{"key":"e_1_2_7_22_1","first-page":"21","article-title":"In vivo determination of extracellular brain ascorbate","volume":"69","author":"MIELE M.","year":"1996","journal-title":"J. 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