{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:04:47Z","timestamp":1771067087930,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2860,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The relative roles of endothelin (ET) and vasopressin (AVP) in the regulation of blood pressure (BP), cardiac output (CO) and total peripheral resistance (TPR) were investigated in the early stages (24\u2003\u2013\u200331 days) of development of hypertension in the conscious deoxycorticosterone acetate (DOCA)\u2010salt hypertensive rat model.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BP was recorded with radiotelemetry devices and CO with ultrasonic transit\u2010time probes. TPR was calculated from the BP and CO recordings. The contributions of endogenous ET and AVP were studied by infusing [d(CH<jats:sub>2<\/jats:sub>)<jats:sub>5<\/jats:sub><jats:sup>1<\/jats:sup>,O\u2010Me_Tyr<jats:sup>2<\/jats:sup>,Arg<jats:sup>8<\/jats:sup>]\u2010vasopressin, a V<jats:sub>1<\/jats:sub>\u2010receptor antagonist, and bosentan, a mixed ET<jats:sub>A<\/jats:sub>\/ET<jats:sub>B<\/jats:sub> receptor antagonist (Study 1). Vascular responsiveness was estimated from the changes in TPR evoked by i.v. infusions of ET\u20101 and AVP (Study 2).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In study 1, infusion of bosentan reduced TPR and BP dramatically in DOCA\u2010salt hypertensive rats but not in SHAM control rats, and this effect was greater when the AVP system had been blocked. In contrast, the V<jats:sub>1<\/jats:sub> receptor antagonist alone failed to change TPR and BP in DOCA\u2010salt hypertensive rats. However, subsequent infusion of the V<jats:sub>1<\/jats:sub> receptor antagonist during the plateau phase of the response in bosentan pretreated DOCA\u2010salt hypertensive rats led to significant decreases in both BP and TPR.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In study 2, TPR and BP responses to ET\u20101, but not AVP, were greater in DOCA\u2010salt rats than in control rats. CO responses to ET\u20101 or AVP were similar in the two groups.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that both ET and AVP play a role in the maintenance of TPR and BP; when one system is blocked the other compensates. However, the magnitude of the contribution to the hypertensive state appears greater for ET than for AVP. Enhanced vascular responses to ET appear to contribute to this greater role.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 1447\u20131454; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0703958\">10.1038\/sj.bjp.0703958<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0703958","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:33:04Z","timestamp":1106947984000},"page":"1447-1454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of endothelin and vasopressin in DOCA\u2010salt hypertension"],"prefix":"10.1111","volume":"132","author":[{"given":"Ming","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Robert McNeill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(98)00042-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199312000-00019"},{"key":"e_1_2_7_4_1","first-page":"838","article-title":"Vasopressin and vascular reactivity in the development of deoxycorticosterone hypertension in rats with hereditary diabetes insipidus","author":"BERECEK K.H.","year":"1980","journal-title":"Circulation"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.6.1191"},{"key":"e_1_2_7_6_1","first-page":"222","article-title":"Alpha and beta adrenoceptor blockade in normotensive and deoxycorticosterone (DOC)\u2010hypertensive rats; plasma vasopressin and vasopressin pressor effect","volume":"224","author":"BURNIER H.","year":"1983","journal-title":"J. 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